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[[Image:2anl.png|left|200px]]


{{STRUCTURE_2anl|  PDB=2anl  |  SCENE=  }}
==X-ray crystal structure of the aspartic protease plasmepsin 4 from the malarial parasite plasmodium malariae bound to an allophenylnorstatine based inhibitor==
 
<StructureSection load='2anl' size='340' side='right'caption='[[2anl]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
===X-ray crystal structure of the aspartic protease plasmepsin 4 from the malarial parasite plasmodium malariae bound to an allophenylnorstatine based inhibitor===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2anl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_malariae Plasmodium malariae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ANL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ANL FirstGlance]. <br>
{{ABSTRACT_PUBMED_16510971}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JE2:(4R)-3-{(2S,3S)-2-HYDROXY-3-[(3-HYDROXY-2-METHYLBENZOYL)AMINO]-4-PHENYLBUTANOYL}-5,5-DIMETHYL-N-(2-METHYLBENZYL)-1,3-THIAZOLIDINE-4-CARBOXAMIDE'>JE2</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2anl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2anl OCA], [https://pdbe.org/2anl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2anl RCSB], [https://www.ebi.ac.uk/pdbsum/2anl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2anl ProSAT]</span></td></tr>
[[2anl]] is a 2 chain structure of [[Plasmepsin]] with sequence from [http://en.wikipedia.org/wiki/Plasmodium_malariae Plasmodium malariae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ANL OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/O60990_PLAMA O60990_PLAMA]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/an/2anl_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2anl ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Plasmepsin|Plasmepsin]]
*[[Plasmepsin|Plasmepsin]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:016510971</ref><references group="xtra"/>
[[Category: Large Structures]]
[[Category: Plasmodium malariae]]
[[Category: Plasmodium malariae]]
[[Category: Agbandje-McKenna, M.]]
[[Category: Agbandje-McKenna M]]
[[Category: Clemente, J C.]]
[[Category: Clemente JC]]
[[Category: Dame, J B.]]
[[Category: Dame JB]]
[[Category: Dunn, B M.]]
[[Category: Dunn BM]]
[[Category: Fisher, S Z.]]
[[Category: Fisher SZ]]
[[Category: Govindasamy, L.]]
[[Category: Govindasamy L]]
[[Category: Hayashi, Y.]]
[[Category: Hayashi Y]]
[[Category: Hidaka, K.]]
[[Category: Hidaka K]]
[[Category: Kimura, T.]]
[[Category: Kimura T]]
[[Category: Kiso, Y.]]
[[Category: Kiso Y]]
[[Category: Madabushi, A.]]
[[Category: Madabushi A]]
[[Category: McKenna, R.]]
[[Category: McKenna R]]
[[Category: Moose, R E.]]
[[Category: Moose RE]]
[[Category: Yowell, C A.]]
[[Category: Yowell CA]]
[[Category: Aspartic protease]]
[[Category: Hydrolase]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Plasmepsin 4]]
[[Category: Plasmodium parasite]]
Retrieved from "https://proteopedia.org/2anl"