3g5e: Difference between revisions

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[[Image:3g5e.png|left|200px]]


{{STRUCTURE_3g5e|  PDB=3g5e  |  SCENE=  }}
==Human aldose reductase complexed with IDD 740 inhibitor==
 
<StructureSection load='3g5e' size='340' side='right'caption='[[3g5e]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
===Human aldose reductase complexed with IDD 740 inhibitor===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3g5e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G5E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G5E FirstGlance]. <br>
{{ABSTRACT_PUBMED_19250825}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=Q74:2-(3-((4,5,7-TRIFLUOROBENZO[D]THIAZOL-2-YL)METHYL)-1H-PYRROLO[2,3-B]PYRIDIN-1-YL)ACETIC+ACID'>Q74</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g5e OCA], [https://pdbe.org/3g5e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g5e RCSB], [https://www.ebi.ac.uk/pdbsum/3g5e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g5e ProSAT]</span></td></tr>
[[3g5e]] is a 1 chain structure of [[Aldose Reductase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G5E OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/ALDR_HUMAN ALDR_HUMAN] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g5/3g5e_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3g5e ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Aldose Reductase|Aldose Reductase]]
*[[Aldose reductase 3D structures|Aldose reductase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:019250825</ref><references group="xtra"/>
[[Category: Aldehyde reductase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Podjarny, A D.]]
[[Category: Large Structures]]
[[Category: Zandt, M C.Van.]]
[[Category: Podjarny AD]]
[[Category: Aldose reductase]]
[[Category: Van Zandt MC]]
[[Category: Cataract]]
[[Category: Diabetes]]
[[Category: Inhibition]]
[[Category: Nadp]]
[[Category: Oxidoreductase]]
[[Category: Phosphoprotein]]
Retrieved from "https://proteopedia.org/3g5e"