1l8a: Difference between revisions

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[[Image:1l8a.png|left|200px]]


{{STRUCTURE_1l8a|  PDB=1l8a  |  SCENE=  }}
==E. COLI PYRUVATE DEHYDROGENASE==
 
<StructureSection load='1l8a' size='340' side='right'caption='[[1l8a]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
===E. COLI PYRUVATE DEHYDROGENASE===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1l8a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L8A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L8A FirstGlance]. <br>
{{ABSTRACT_PUBMED_11955070}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TPP:THIAMINE+DIPHOSPHATE'>TPP</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l8a OCA], [https://pdbe.org/1l8a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l8a RCSB], [https://www.ebi.ac.uk/pdbsum/1l8a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l8a ProSAT]</span></td></tr>
[[1l8a]] is a 2 chain structure of [[Pyruvate dehydrogenase]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L8A OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/ODP1_ECOLI ODP1_ECOLI] Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l8/1l8a_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1l8a ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Pyruvate dehydrogenase|Pyruvate dehydrogenase]]
*[[Pyruvate dehydrogenase|Pyruvate dehydrogenase]]
 
*[[Pyruvate dehydrogenase 3D structures|Pyruvate dehydrogenase 3D structures]]
==Reference==
__TOC__
<ref group="xtra">PMID:011955070</ref><ref group="xtra">PMID:012651851</ref><references group="xtra"/>
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Arjunan, P.]]
[[Category: Large Structures]]
[[Category: Furey, W.]]
[[Category: Arjunan P]]
[[Category: Alpha-keto acid dehydrogenase]]
[[Category: Furey W]]
[[Category: Oxidoreductase]]
[[Category: Pyruvate]]
[[Category: Thiamin diphosphate]]
Retrieved from "https://proteopedia.org/1l8a"