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[[Image:1fbl.png|left|200px]]


{{STRUCTURE_1fbl|  PDB=1fbl  |  SCENE=  }}
==STRUCTURE OF FULL-LENGTH PORCINE SYNOVIAL COLLAGENASE (MMP1) REVEALS A C-TERMINAL DOMAIN CONTAINING A CALCIUM-LINKED, FOUR-BLADED BETA-PROPELLER==
 
<StructureSection load='1fbl' size='340' side='right'caption='[[1fbl]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
===STRUCTURE OF FULL-LENGTH PORCINE SYNOVIAL COLLAGENASE (MMP1) REVEALS A C-TERMINAL DOMAIN CONTAINING A CALCIUM-LINKED, FOUR-BLADED BETA-PROPELLER===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1fbl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FBL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FBL FirstGlance]. <br>
{{ABSTRACT_PUBMED_8590015}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HTA:N-[3-(N-HYDROXYCARBOXAMIDO)-2-(2-METHYLPROPYL)-PROPANOYL]-O-TYROSINE-N-METHYLAMIDE'>HTA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fbl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fbl OCA], [https://pdbe.org/1fbl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fbl RCSB], [https://www.ebi.ac.uk/pdbsum/1fbl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fbl ProSAT]</span></td></tr>
[[1fbl]] is a 1 chain structure of [[Matrix metalloproteinase]] with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FBL OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/MMP1_PIG MMP1_PIG] Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fb/1fbl_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fbl ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Matrix metalloproteinase|Matrix metalloproteinase]]
*[[Matrix metalloproteinase 3D structures|Matrix metalloproteinase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:008590015</ref><references group="xtra"/>
[[Category: Large Structures]]
[[Category: Interstitial collagenase]]
[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
[[Category: Blow, D M.]]
[[Category: Blow DM]]
[[Category: Brick, P.]]
[[Category: Brick P]]
[[Category: Li, J.]]
[[Category: Li J]]
[[Category: Metalloprotease]]
Retrieved from "https://proteopedia.org/1fbl"