1hfu: Difference between revisions

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[[Image:1hfu.gif|left|200px]]<br />
<applet load="1hfu" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1hfu, resolution 1.68&Aring;" />
'''TYPE-2 CU-DEPLETED LACCASE FROM COPRINUS CINEREUS AT 1.68 A RESOLUTION'''<br />


==Overview==
==TYPE-2 CU-DEPLETED LACCASE FROM COPRINUS CINEREUS at 1.68 A resolution==
Laccases (E.C. 1.10.3.2; benzenediol oxygen oxidoreductases) couple the, four-electron reduction of dioxygen to water to four one-electron, oxidations of a reducing substrate. The three-dimensional structure of the, 'blue' multi-copper oxidase laccase from the fungus Coprinus cinereus at, 1.68 A reveals the structural basis for isoforms of the type 2 Cu-depleted, species.
<StructureSection load='1hfu' size='340' side='right'caption='[[1hfu]], [[Resolution|resolution]] 1.68&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1hfu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Coprinopsis_cinerea Coprinopsis cinerea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HFU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HFU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.68&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hfu OCA], [https://pdbe.org/1hfu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hfu RCSB], [https://www.ebi.ac.uk/pdbsum/1hfu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hfu ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q9Y780_COPCI Q9Y780_COPCI]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hf/1hfu_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hfu ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Laccases (E.C. 1.10.3.2; benzenediol oxygen oxidoreductases) couple the four-electron reduction of dioxygen to water to four one-electron oxidations of a reducing substrate. The three-dimensional structure of the 'blue' multi-copper oxidase laccase from the fungus Coprinus cinereus at 1.68 A reveals the structural basis for isoforms of the type 2 Cu-depleted species.


==About this Structure==
Structure of the laccase from Coprinus cinereus at 1.68 A resolution: evidence for different 'type 2 Cu-depleted' isoforms.,Ducros V, Brzozowski AM, Wilson KS, Ostergaard P, Schneider P, Svendson A, Davies GJ Acta Crystallogr D Biol Crystallogr. 2001 Feb;57(Pt 2):333-6. PMID:11173497<ref>PMID:11173497</ref>
1HFU is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Coprinopsis_cinerea Coprinopsis cinerea]] with CU as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Laccase Laccase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.3.2 1.10.3.2]]. Structure known Active Site: T1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HFU OCA]].


==Reference==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
Structure of the laccase from Coprinus cinereus at 1.68 A resolution: evidence for different 'type 2 Cu-depleted' isoforms., Ducros V, Brzozowski AM, Wilson KS, Ostergaard P, Schneider P, Svendson A, Davies GJ, Acta Crystallogr D Biol Crystallogr. 2001 Feb;57(Pt 2):333-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11173497 11173497]
</div>
<div class="pdbe-citations 1hfu" style="background-color:#fffaf0;"></div>
 
==See Also==
*[[Laccase 3D structures|Laccase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Coprinopsis cinerea]]
[[Category: Coprinopsis cinerea]]
[[Category: Laccase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Brzozowski AM]]
[[Category: Brzozowski, A.M.]]
[[Category: Ducros V]]
[[Category: Davies, G.J.]]
[[Category: Ducros, V.]]
[[Category: CU]]
[[Category: blue multi-copper oxidase]]
[[Category: glycoprotein]]
[[Category: laccase]]
[[Category: oxidoreductase]]
[[Category: signal]]
[[Category: type-2 copper depleted]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:49:08 2007''
Retrieved from "https://proteopedia.org/1hfu"