3d0b: Difference between revisions

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[[Image:3d0b.png|left|200px]]


{{STRUCTURE_3d0b|  PDB=3d0b  |  SCENE=  }}
==Crystal Structure of Benzamide Tetrahydro-4H-carbazol-4-one bound to Hsp90==
 
<StructureSection load='3d0b' size='340' side='right'caption='[[3d0b]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
===Crystal Structure of Benzamide Tetrahydro-4H-carbazol-4-one bound to Hsp90===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3d0b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D0B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3D0B FirstGlance]. <br>
{{ABSTRACT_PUBMED_18511277}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.74&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SNX:2-[(2-METHOXYETHYL)AMINO]-4-(4-OXO-1,2,3,4-TETRAHYDRO-9H-CARBAZOL-9-YL)BENZAMIDE'>SNX</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3d0b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d0b OCA], [https://pdbe.org/3d0b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3d0b RCSB], [https://www.ebi.ac.uk/pdbsum/3d0b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3d0b ProSAT]</span></td></tr>
[[3d0b]] is a 1 chain structure of [[Heat Shock Proteins]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D0B OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d0/3d0b_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3d0b ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Heat Shock Proteins|Heat Shock Proteins]]
*[[Heat Shock Protein structures|Heat Shock Protein structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:018511277</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Barta, T E.]]
[[Category: Large Structures]]
[[Category: Hall, S H.]]
[[Category: Barta TE]]
[[Category: Huang, K H.]]
[[Category: Hall SH]]
[[Category: Veal, J M.]]
[[Category: Huang KH]]
[[Category: Atp-binding]]
[[Category: Veal JM]]
[[Category: Chaperone]]
[[Category: Heat shock protein 90]]
[[Category: Hsp90]]
[[Category: Nucleotide-binding]]
[[Category: Phosphoprotein]]
[[Category: Stress response]]
Retrieved from "https://proteopedia.org/3d0b"