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[[Image:3cpw.png|left|200px]]


{{STRUCTURE_3cpw|  PDB=3cpw  |  SCENE=  }}
==The structure of the antibiotic LINEZOLID bound to the large ribosomal subunit of HALOARCULA MARISMORTUI==
 
<StructureSection load='3cpw' size='340' side='right'caption='[[3cpw]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
===The structure of the antibiotic LINEZOLID bound to the large ribosomal subunit of HALOARCULA MARISMORTUI===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3cpw]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Haloarcula_marismortui Haloarcula marismortui]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CPW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CPW FirstGlance]. <br>
{{ABSTRACT_PUBMED_18494460}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SR:STRONTIUM+ION'>SR</scene>, <scene name='pdbligand=ZLD:N-{[(5S)-3-(3-FLUORO-4-MORPHOLIN-4-YLPHENYL)-2-OXO-1,3-OXAZOLIDIN-5-YL]METHYL}ACETAMIDE'>ZLD</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cpw OCA], [https://pdbe.org/3cpw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cpw RCSB], [https://www.ebi.ac.uk/pdbsum/3cpw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cpw ProSAT]</span></td></tr>
[[3cpw]] is a 30 chain structure of [[Ribosomal protein L10]], [[Ribosomal protein L13]], [[Ribosomal protein L19]], [[Ribosomal protein L2]], [[Ribosomal protein L21]], [[Ribosomal protein L3]], [[Ribosomal protein L34]], [[Ribosomal protein L4]], [[Ribosomal protein L5]], [[Ribosomal protein L6]] and [[Ribosomal protein L7]] with sequence from [http://en.wikipedia.org/wiki/Haloarcula_marismortui Haloarcula marismortui]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CPW OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/RL3_HALMA RL3_HALMA] One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity).[HAMAP-Rule:MF_01325_A]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cp/3cpw_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cpw ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Ribosomal protein L10|Ribosomal protein L10]]
*[[Ribosome 3D structures|Ribosome 3D structures]]
*[[Ribosomal protein L13|Ribosomal protein L13]]
__TOC__
*[[Ribosomal protein L19|Ribosomal protein L19]]
</StructureSection>
*[[Ribosomal protein L2|Ribosomal protein L2]]
*[[Ribosomal protein L21|Ribosomal protein L21]]
*[[Ribosomal protein L3|Ribosomal protein L3]]
*[[Ribosomal protein L34|Ribosomal protein L34]]
*[[Ribosomal protein L4|Ribosomal protein L4]]
*[[Ribosomal protein L5|Ribosomal protein L5]]
*[[Ribosomal protein L6|Ribosomal protein L6]]
*[[Ribosomal protein L7|Ribosomal protein L7]]
 
==Reference==
<ref group="xtra">PMID:018494460</ref><references group="xtra"/>
[[Category: Haloarcula marismortui]]
[[Category: Haloarcula marismortui]]
[[Category: Duffy, E M.]]
[[Category: Large Structures]]
[[Category: Franceschi, F J.]]
[[Category: Duffy EM]]
[[Category: Ippolito, J A.]]
[[Category: Franceschi FJ]]
[[Category: Kanyo, Z K.]]
[[Category: Ippolito JA]]
[[Category: Moore, P B.]]
[[Category: Kanyo ZK]]
[[Category: Steitz, T A.]]
[[Category: Moore PB]]
[[Category: Wang, D.]]
[[Category: Steitz TA]]
[[Category: 50s ribosomal subunit]]
[[Category: Wang D]]
[[Category: Antibiotic complex]]
[[Category: Linezolid]]
[[Category: Metal-binding]]
[[Category: Ribonucleoprotein]]
[[Category: Ribosomal protein]]
[[Category: Ribosome]]
[[Category: Rna-binding]]
[[Category: Rrna-binding]]
[[Category: Trna-binding]]
[[Category: Zinc-finger]]
Retrieved from "https://proteopedia.org/3cpw"