3fyx: Difference between revisions

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[[Image:3fyx.png|left|200px]]


{{STRUCTURE_3fyx| PDB=3fyx | SCENE= }}
==The Structure of OmpF porin with a synthetic dibenzo-18-crown-6 as modulator==
<StructureSection load='3fyx' size='340' side='right'caption='[[3fyx]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3fyx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FYX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FYX FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=451:N-(6,7,9,10,17,18,20,21-OCTAHYDRODIBENZO[B,K][1,4,7,10,13,16]HEXAOXACYCLOOCTADECIN-2-YL)ACETAMIDE'>451</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fyx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fyx OCA], [https://pdbe.org/3fyx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fyx RCSB], [https://www.ebi.ac.uk/pdbsum/3fyx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fyx ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/OMPF_ECOLI OMPF_ECOLI] Forms pores that allow passive diffusion of small molecules across the outer membrane. It is also a receptor for the bacteriophage T2.<ref>PMID:19721064</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fy/3fyx_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fyx ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The attachment of modulators to a trimeric porin ion channel was investigated (see picture of the trimer with a crown ether modulator (orange)). The interplay of modulator and protein is essential for the conformational heterogeneity of the hybrid channel. Single-site attachment in large pores is not sufficient to change the electrophysiological characteristics of the pores-such change requires additional noncovalent interactions or second-site attachments.


===The Structure of OmpF porin with a synthetic dibenzo-18-crown-6 as modulator===
On the function and structure of synthetically modified porins.,Reitz S, Cebi M, Reiss P, Studnik G, Linne U, Koert U, Essen LO Angew Chem Int Ed Engl. 2009;48(26):4853-7. PMID:19322865<ref>PMID:19322865</ref>


{{ABSTRACT_PUBMED_19322865}}
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
==About this Structure==
<div class="pdbe-citations 3fyx" style="background-color:#fffaf0;"></div>
[[3fyx]] is a 1 chain structure of [[Porin]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k12 Escherichia coli k12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FYX OCA].


==See Also==
==See Also==
*[[Porin|Porin]]
*[[Porin 3D structures|Porin 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:019322865</ref><references group="xtra"/>
__TOC__
[[Category: Escherichia coli k12]]
</StructureSection>
[[Category: Cebi, M.]]
[[Category: Escherichia coli K-12]]
[[Category: Essen, L O.]]
[[Category: Large Structures]]
[[Category: Koert, U.]]
[[Category: Cebi M]]
[[Category: Reitz, S.]]
[[Category: Essen LO]]
[[Category: Beta-barrel]]
[[Category: Koert U]]
[[Category: Cell membrane]]
[[Category: Reitz S]]
[[Category: Cell outer membrane]]
[[Category: Crown ether]]
[[Category: Ion transport]]
[[Category: Ion-channel engineering]]
[[Category: Membrane]]
[[Category: Phage recognition]]
[[Category: Porin]]
[[Category: Porin structure]]
[[Category: Synthetic ion-current modulator]]
[[Category: Transmembrane]]
[[Category: Transport]]
[[Category: Transport protein]]
Retrieved from "https://proteopedia.org/3fyx"