2fdd: Difference between revisions

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[[Image:2fdd.png|left|200px]]


{{STRUCTURE_2fdd|  PDB=2fdd  |  SCENE=  }}
==Crystal structure of HIV protease D545701 bound with GW0385==
 
<StructureSection load='2fdd' size='340' side='right'caption='[[2fdd]], [[Resolution|resolution]] 1.58&Aring;' scene=''>
===Crystal structure of HIV protease D545701 bound with GW0385===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2fdd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FDD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FDD FirstGlance]. <br>
{{ABSTRACT_PUBMED_16458505}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.58&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=385:(3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL+[(1S,2R)-3-[(1,3-BENZODIOXOL-5-YLSULFONYL)(ISOBUTYL)AMINO]-2-HYDROXY-1-{4-[(2-METHYL-1,3-THIAZOL-4-YL)METHOXY]BENZYL}PROPYL]CARBAMATE'>385</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fdd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fdd OCA], [https://pdbe.org/2fdd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fdd RCSB], [https://www.ebi.ac.uk/pdbsum/2fdd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fdd ProSAT]</span></td></tr>
[[2fdd]] is a 2 chain structure of [[Virus protease]] with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FDD OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q7SPG9_9HIV1 Q7SPG9_9HIV1]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fd/2fdd_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fdd ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Virus protease|Virus protease]]
*[[Immunodeficiency virus protease 3D structures|Immunodeficiency virus protease 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:016458505</ref><references group="xtra"/>
[[Category: HIV-1 retropepsin]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Xu, R X.]]
[[Category: Large Structures]]
[[Category: Hiv protease]]
[[Category: Xu RX]]
[[Category: Hydrolase]]
[[Category: Inhibitor]]
Retrieved from "https://proteopedia.org/2fdd"