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[[Image:2cmd.png|left|200px]]


{{STRUCTURE_2cmd|  PDB=2cmd  |  SCENE=  }}
==THE CRYSTAL STRUCTURE OF E.COLI MALATE DEHYDROGENASE: A COMPLEX OF THE APOENZYME AND CITRATE AT 1.87 ANGSTROMS RESOLUTION==
 
<StructureSection load='2cmd' size='340' side='right'caption='[[2cmd]], [[Resolution|resolution]] 1.87&Aring;' scene=''>
===THE CRYSTAL STRUCTURE OF E.COLI MALATE DEHYDROGENASE: A COMPLEX OF THE APOENZYME AND CITRATE AT 1.87 ANGSTROMS RESOLUTION===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2cmd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CMD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CMD FirstGlance]. <br>
{{ABSTRACT_PUBMED_1507230}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.87&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cmd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cmd OCA], [https://pdbe.org/2cmd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cmd RCSB], [https://www.ebi.ac.uk/pdbsum/2cmd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cmd ProSAT]</span></td></tr>
[[2cmd]] is a 1 chain structure of [[Johnson sandbox 1]] and [[Malate dehydrogenase]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CMD OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/MDH_ECOLI MDH_ECOLI] Catalyzes the reversible oxidation of malate to oxaloacetate.[HAMAP-Rule:MF_01516]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cm/2cmd_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cmd ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Johnson sandbox 1|Johnson sandbox 1]]
*[[Malate Dehydrogenase 3D structures|Malate Dehydrogenase 3D structures]]
*[[Malate dehydrogenase|Malate dehydrogenase]]
__TOC__
 
</StructureSection>
==Reference==
<ref group="xtra">PMID:001507230</ref><ref group="xtra">PMID:011742118</ref><ref group="xtra">PMID:012215419</ref><references group="xtra"/>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Malate dehydrogenase]]
[[Category: Large Structures]]
[[Category: Banaszak, L J.]]
[[Category: Banaszak LJ]]
[[Category: Hall, M D.]]
[[Category: Hall MD]]
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