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[[Image:2dsf.png|left|200px]]


{{STRUCTURE_2dsf|  PDB=2dsf  |  SCENE=  }}
==Structure of the complex of C-terminal lobe of bovine lactoferrin with xylose at 2.8A resolution==
 
<StructureSection load='2dsf' size='340' side='right'caption='[[2dsf]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
===Structure of the complex of C-terminal lobe of bovine lactoferrin with xylose at 2.8A resolution===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2dsf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DSF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DSF FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
==About this Structure==
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=LXC:BETA-L-XYLOPYRANOSE'>LXC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
[[2dsf]] is a 1 chain structure of [[Lactoferrin]] with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DSF OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dsf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dsf OCA], [https://pdbe.org/2dsf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dsf RCSB], [https://www.ebi.ac.uk/pdbsum/2dsf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dsf ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TRFL_BOVIN TRFL_BOVIN] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref>  Lactotransferrin has antimicrobial activity. The most effective inhibitory activity was seen against E.coli and P.aeruginosa.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref>  Lactoferricin B is an antimicrobial peptide. Inhibits the growth of Gram-negative and Gram-positive bacteria.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref>  The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ds/2dsf_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dsf ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Lactoferrin|Lactoferrin]]
*[[Lactoferrin|Lactoferrin]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Bhushan, A.]]
[[Category: Large Structures]]
[[Category: Mir, R.]]
[[Category: Bhushan A]]
[[Category: Sharma, S.]]
[[Category: Mir R]]
[[Category: Singh, N.]]
[[Category: Sharma S]]
[[Category: Singh, T P.]]
[[Category: Singh N]]
[[Category: Sinha, M.]]
[[Category: Singh TP]]
[[Category: Complex]]
[[Category: Sinha M]]
[[Category: Metal binding protein]]
[[Category: Sugar]]
Retrieved from "https://proteopedia.org/2dsf"