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[[Image:2hgl.png|left|200px]]


{{STRUCTURE_2hgl|  PDB=2hgl  |  SCENE=  }}
==NMR structure of the first qRRM domain of human hnRNP F==
 
<StructureSection load='2hgl' size='340' side='right'caption='[[2hgl]]' scene=''>
===NMR structure of the first qRRM domain of human hnRNP F===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2hgl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HGL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HGL FirstGlance]. <br>
{{ABSTRACT_PUBMED_16885237}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hgl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hgl OCA], [https://pdbe.org/2hgl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hgl RCSB], [https://www.ebi.ac.uk/pdbsum/2hgl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hgl ProSAT]</span></td></tr>
==About this Structure==
</table>
[[2hgl]] is a 1 chain structure of [[Nucleoprotein]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HGL OCA].  
== Function ==
[https://www.uniprot.org/uniprot/HNRPF_HUMAN HNRPF_HUMAN] Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state.<ref>PMID:20526337</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hg/2hgl_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hgl ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Nucleoprotein|Nucleoprotein]]
*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:016885237</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Allain, F H.T]]
[[Category: Large Structures]]
[[Category: Dominguez, C.]]
[[Category: Allain FH-T]]
[[Category: Alternative]]
[[Category: Dominguez C]]
[[Category: G-quadruplex]]
[[Category: G-tract]]
[[Category: Rna binding protein]]
[[Category: Rna recognition motif]]
[[Category: Splicing]]
Retrieved from "https://proteopedia.org/2hgl"