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[[Image:2cit.png|left|200px]]


{{STRUCTURE_2cit|  PDB=2cit  |  SCENE= }}
==Structure of the covalent intermediate of a family 26 lichenase==
 
<StructureSection load='2cit' size='340' side='right'caption='[[2cit]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
===STRUCTURE OF THE COVALENT INTERMEDIATE OF A FAMILY 26 LICHENASE===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2cit]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Acetivibrio_thermocellus Acetivibrio thermocellus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CIT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CIT FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
==About this Structure==
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=G2F:2-DEOXY-2-FLUORO-ALPHA-D-GLUCOPYRANOSE'>G2F</scene></td></tr>
[[2cit]] is a 1 chain structure of [[Glucanase]] with sequence from [http://en.wikipedia.org/wiki/Clostridium_thermocellum Clostridium thermocellum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CIT OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cit OCA], [https://pdbe.org/2cit PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cit RCSB], [https://www.ebi.ac.uk/pdbsum/2cit PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cit ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GUNH_ACET2 GUNH_ACET2] This enzyme catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ci/2cit_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cit ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Glucanase|Glucanase]]
*[[Glucanase 3D structures|Glucanase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:016823793</ref><references group="xtra"/>
[[Category: Acetivibrio thermocellus]]
[[Category: Cellulase]]
[[Category: Large Structures]]
[[Category: Clostridium thermocellum]]
[[Category: Davies GJ]]
[[Category: Davies, G J.]]
[[Category: Gilbert HJ]]
[[Category: Gilbert, H J.]]
[[Category: Money VA]]
[[Category: Money, V A.]]
[[Category: Scaffidi A]]
[[Category: Scaffidi, A.]]
[[Category: Smith NL]]
[[Category: Smith, N L.]]
[[Category: Stick RV]]
[[Category: Stick, R V.]]
[[Category: Carbohydrate metabolism]]
[[Category: Cellulose degradation]]
[[Category: Glycosidase]]
[[Category: Glycoside hydrolase]]
[[Category: Hydrolase]]
[[Category: Lichenase]]
[[Category: Michaelis complex]]
[[Category: Polysaccharide degradation]]

Latest revision as of 05:08, 17 October 2024

Structure of the covalent intermediate of a family 26 lichenase

2cit, resolution 1.40Å

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