2l0x: Difference between revisions

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[[Image:2l0x.png|left|200px]]


{{STRUCTURE_2l0x|  PDB=2l0x  |  SCENE=  }}
==Solution structure of the 21 kDa GTPase RHEB bound to GDP==
 
<StructureSection load='2l0x' size='340' side='right'caption='[[2l0x]]' scene=''>
===Solution structure of the 21 kDa GTPase RHEB bound to GDP===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2l0x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L0X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L0X FirstGlance]. <br>
{{ABSTRACT_PUBMED_20685651}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l0x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l0x OCA], [https://pdbe.org/2l0x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l0x RCSB], [https://www.ebi.ac.uk/pdbsum/2l0x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l0x ProSAT]</span></td></tr>
[[2l0x]] is a 1 chain structure of [[GTP-binding protein]] with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L0X OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/RHEB_RAT RHEB_RAT] Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Activates the protein kinase activity of mTORC1. Has low intrinsic GTPase activity (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l0/2l0x_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2l0x ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[GTP-binding protein|GTP-binding protein]]
*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:020685651</ref><references group="xtra"/>
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Berghaus, C.]]
[[Category: Berghaus C]]
[[Category: Heumann, R.]]
[[Category: Heumann R]]
[[Category: Kock, G.]]
[[Category: Kock G]]
[[Category: Stoll, R.]]
[[Category: Stoll R]]
[[Category: Gtpase]]
[[Category: Hydrolase]]
Retrieved from "https://proteopedia.org/2l0x"