2fm2: Difference between revisions
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==HCV NS3-4A protease domain complexed with a ketoamide inhibitor, SCH446211== | |||
<StructureSection load='2fm2' size='340' side='right'caption='[[2fm2]], [[Resolution|resolution]] 2.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2fm2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepacivirus_C Hepacivirus C] and [https://en.wikipedia.org/wiki/Hepatitis_C_virus_genotype_1a Hepatitis C virus genotype 1a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FM2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FM2 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3BC:TERT-BUTYL+[(1S)-1-({(1R,2S,5S)-2-[(3S,10S)-3-(CYCLOPROPYLMETHYL)-12-METHYL-4,5,8,11-TETRAOXO-10-PHENYL-2,6,9,12-TETRAAZATRIDECAN-1+-OYL]-6,6-DIMETHYL-3-AZABICYCLO[3.1.0]HEX-3-YL}CARBONYL)-2,2-DIMETHYLPROPYL]CARBAMATE'>3BC</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
== | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fm2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fm2 OCA], [https://pdbe.org/2fm2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fm2 RCSB], [https://www.ebi.ac.uk/pdbsum/2fm2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fm2 ProSAT]</span></td></tr> | ||
[[2fm2]] is a 4 chain structure | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/Q9ELS8_9HEPC Q9ELS8_9HEPC] | |||
==See Also== | ==See Also== | ||
*[[Helicase|Helicase]] | *[[Helicase 3D structures|Helicase 3D structures]] | ||
*[[Virus protease 3D structures|Virus protease 3D structures]] | |||
__TOC__ | |||
< | </StructureSection> | ||
[[Category: Hepatitis | [[Category: Hepacivirus C]] | ||
[[Category: Bogen | [[Category: Hepatitis C virus genotype 1a]] | ||
[[Category: Bourne | [[Category: Large Structures]] | ||
[[Category: Chase | [[Category: Bogen SL]] | ||
[[Category: Chen | [[Category: Bourne N]] | ||
[[Category: Lemon | [[Category: Chase R]] | ||
[[Category: Malcolm | [[Category: Chen T]] | ||
[[Category: Njoroge | [[Category: Lemon SM]] | ||
[[Category: Prongay | [[Category: Malcolm BA]] | ||
[[Category: Pyles | [[Category: Njoroge FG]] | ||
[[Category: Saksena | [[Category: Prongay A]] | ||
[[Category: Skelton | [[Category: Pyles RB]] | ||
[[Category: Tong | [[Category: Saksena AK]] | ||
[[Category: Veselenak | [[Category: Skelton A]] | ||
[[Category: Yi | [[Category: Tong X]] | ||
[[Category: Veselenak RL]] | |||
[[Category: Yi M]] | |||
Latest revision as of 06:26, 3 April 2024
HCV NS3-4A protease domain complexed with a ketoamide inhibitor, SCH446211
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