1ds9: Difference between revisions
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==SOLUTION STRUCTURE OF CHLAMYDOMONAS OUTER ARM DYNEIN LIGHT CHAIN 1== | |||
<StructureSection load='1ds9' size='340' side='right'caption='[[1ds9]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1ds9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Chlamydomonas_reinhardtii Chlamydomonas reinhardtii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DS9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DS9 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ds9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ds9 OCA], [https://pdbe.org/1ds9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ds9 RCSB], [https://www.ebi.ac.uk/pdbsum/1ds9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ds9 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/DNAL1_CHLRE DNAL1_CHLRE] Associates with the gamma heavy chain in the outer arm dynein. May target p45 polypeptide (an 45 kDa axonemal component) to the motor domain of the gamma heavy chain dynein.<ref>PMID:10353837</ref> | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ds/1ds9_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ds9 ConSurf]. | |||
<div style="clear:both"></div> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Dyneins are molecular motors that translocate towards the minus ends of microtubules. In Chlamydomonas flagellar outer arm dynein, light chain 1 (LC1) associates with the nucleotide binding region within the gamma heavy chain motor domain and consists of a central leucine-rich repeat section that folds as a cylindrical right handed spiral formed from six beta-beta-alpha motifs. This central cylinder is flanked by terminal helical subdomains. The C-terminal helical domain juts out from the cylinder and is adjacent to a hydrophobic surface within the repeat region that is proposed to interact with the dynein heavy chain. The position of the C-terminal domain on LC1 and the unexpected structural similarity between LC1 and U2A' from the human spliceosome suggest that this domain interacts with the dynein motor domain. | |||
Solution structure of a dynein motor domain associated light chain.,Wu H, Maciejewski MW, Marintchev A, Benashski SE, Mullen GP, King SM Nat Struct Biol. 2000 Jul;7(7):575-9. PMID:10876244<ref>PMID:10876244</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 1ds9" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
*[[Dynein|Dynein]] | *[[Dynein 3D structures|Dynein 3D structures]] | ||
== References == | |||
== | <references/> | ||
< | __TOC__ | ||
</StructureSection> | |||
[[Category: Chlamydomonas reinhardtii]] | [[Category: Chlamydomonas reinhardtii]] | ||
[[Category: Benashski | [[Category: Large Structures]] | ||
[[Category: King | [[Category: Benashski SE]] | ||
[[Category: Maciejewski | [[Category: King SM]] | ||
[[Category: Marintchev | [[Category: Maciejewski MW]] | ||
[[Category: Mullen | [[Category: Marintchev A]] | ||
[[Category: Wu | [[Category: Mullen GP]] | ||
[[Category: Wu HW]] | |||
Latest revision as of 08:25, 22 May 2024
SOLUTION STRUCTURE OF CHLAMYDOMONAS OUTER ARM DYNEIN LIGHT CHAIN 1
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