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[[Image:1jaq.png|left|200px]]


{{STRUCTURE_1jaq|  PDB=1jaq  |  SCENE=  }}
==COMPLEX OF 1-HYDROXYLAMINE-2-ISOBUTYLMALONYL-ALA-GLY-NH2 WITH THE CATALYTIC DOMAIN OF MATRIX METALLO PROTEINASE-8 (MET80 FORM)==
 
<StructureSection load='1jaq' size='340' side='right'caption='[[1jaq]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
===COMPLEX OF 1-HYDROXYLAMINE-2-ISOBUTYLMALONYL-ALA-GLY-NH2 WITH THE CATALYTIC DOMAIN OF MATRIX METALLO PROTEINASE-8 (MET80 FORM)===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1jaq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JAQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JAQ FirstGlance]. <br>
{{ABSTRACT_PUBMED_7737183}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=01S:N-[(2R)-2-(HYDROXYCARBAMOYL)-4-METHYLPENTANOYL]-L-ALANYLGLYCINAMIDE'>01S</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jaq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jaq OCA], [https://pdbe.org/1jaq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jaq RCSB], [https://www.ebi.ac.uk/pdbsum/1jaq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jaq ProSAT]</span></td></tr>
[[1jaq]] is a 1 chain structure of [[Matrix metalloproteinase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JAQ OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/MMP8_HUMAN MMP8_HUMAN] Can degrade fibrillar type I, II, and III collagens.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ja/1jaq_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jaq ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Matrix metalloproteinase|Matrix metalloproteinase]]
*[[Matrix metalloproteinase 3D structures|Matrix metalloproteinase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:007737183</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Neutrophil collagenase]]
[[Category: Large Structures]]
[[Category: Bode, W.]]
[[Category: Bode W]]
[[Category: Grams, F.]]
[[Category: Grams F]]
[[Category: Huber, R.]]
[[Category: Huber R]]
[[Category: Kleine, T.]]
[[Category: Kleine T]]
[[Category: Piper, M.]]
[[Category: Piper M]]
[[Category: Powers, J C.]]
[[Category: Powers JC]]
[[Category: Reinemer, P.]]
[[Category: Reinemer P]]
[[Category: Tschesche, H.]]
[[Category: Tschesche H]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Metalloprotease]]
[[Category: Metzincin]]
[[Category: Zinc-endopeptidase]]
Retrieved from "https://proteopedia.org/1jaq"