3k2i: Difference between revisions
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==Human Acyl-coenzyme A thioesterase 4== | |||
<StructureSection load='3k2i' size='340' side='right'caption='[[3k2i]], [[Resolution|resolution]] 2.40Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3k2i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K2I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3K2I FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | |||
== | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr> | ||
[[3k2i]] is a 2 chain structure | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3k2i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k2i OCA], [https://pdbe.org/3k2i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3k2i RCSB], [https://www.ebi.ac.uk/pdbsum/3k2i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3k2i ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ACOT4_HUMAN ACOT4_HUMAN] Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (By similarity). Succinyl-CoA thioesterase that also hydrolyzes long chain saturated and unsaturated monocarboxylic acyl-CoAs. | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k2/3k2i_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3k2i ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | ==See Also== | ||
*[[Thioesterase|Thioesterase]] | *[[Thioesterase 3D structures|Thioesterase 3D structures]] | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Arrowsmith | [[Category: Arrowsmith CH]] | ||
[[Category: Berglund H]] | |||
[[Category: Berglund | [[Category: Bountra C]] | ||
[[Category: Bountra | [[Category: Collins R]] | ||
[[Category: Collins | [[Category: Edwards AM]] | ||
[[Category: Edwards | [[Category: Flodin S]] | ||
[[Category: Flodin | [[Category: Flores A]] | ||
[[Category: Flores | [[Category: Graslund S]] | ||
[[Category: Graslund | [[Category: Hammarstrom M]] | ||
[[Category: Hammarstrom | [[Category: Johansson A]] | ||
[[Category: Johansson | [[Category: Johansson I]] | ||
[[Category: Johansson | [[Category: Kallas A]] | ||
[[Category: Kallas | [[Category: Karlberg T]] | ||
[[Category: Karlberg | [[Category: Kotenyova T]] | ||
[[Category: Kotenyova | [[Category: Kotzsch A]] | ||
[[Category: Kotzsch | [[Category: Kraulis P]] | ||
[[Category: Kraulis | [[Category: Markova N]] | ||
[[Category: Markova | [[Category: Moche M]] | ||
[[Category: Moche | [[Category: Nielsen TK]] | ||
[[Category: Nielsen | [[Category: Nordlund P]] | ||
[[Category: Nordlund | [[Category: Nyman T]] | ||
[[Category: Nyman | [[Category: Persson C]] | ||
[[Category: Persson | [[Category: Roos AK]] | ||
[[Category: Roos | [[Category: Schuler H]] | ||
[[Category: Schutz P]] | |||
[[Category: Schuler | [[Category: Siponen MI]] | ||
[[Category: Schutz | [[Category: Svensson L]] | ||
[[Category: Siponen | [[Category: Thorsell AG]] | ||
[[Category: Svensson | [[Category: Tresaugues L]] | ||
[[Category: Thorsell | [[Category: Van Den Berg S]] | ||
[[Category: Tresaugues | [[Category: Wahlberg E]] | ||
[[Category: Wahlberg | [[Category: Weigelt J]] | ||
[[Category: Weigelt | [[Category: Welin M]] | ||
[[Category: Welin | [[Category: Wisniewska M]] | ||
[[Category: Wisniewska | |||
Latest revision as of 16:06, 1 November 2023
Human Acyl-coenzyme A thioesterase 4
| ||||||||||||
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Homo sapiens
- Large Structures
- Arrowsmith CH
- Berglund H
- Bountra C
- Collins R
- Edwards AM
- Flodin S
- Flores A
- Graslund S
- Hammarstrom M
- Johansson A
- Johansson I
- Kallas A
- Karlberg T
- Kotenyova T
- Kotzsch A
- Kraulis P
- Markova N
- Moche M
- Nielsen TK
- Nordlund P
- Nyman T
- Persson C
- Roos AK
- Schuler H
- Schutz P
- Siponen MI
- Svensson L
- Thorsell AG
- Tresaugues L
- Van Den Berg S
- Wahlberg E
- Weigelt J
- Welin M
- Wisniewska M
