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[[Image:1a2x.png|left|200px]]


{{STRUCTURE_1a2x|  PDB=1a2x  |  SCENE=  }}
==COMPLEX OF TROPONIN C WITH A 47 RESIDUE (1-47) FRAGMENT OF TROPONIN I==
 
<StructureSection load='1a2x' size='340' side='right'caption='[[1a2x]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
===COMPLEX OF TROPONIN C WITH A 47 RESIDUE (1-47) FRAGMENT OF TROPONIN I===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1a2x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A2X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A2X FirstGlance]. <br>
{{ABSTRACT_PUBMED_9560191}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a2x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a2x OCA], [https://pdbe.org/1a2x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a2x RCSB], [https://www.ebi.ac.uk/pdbsum/1a2x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a2x ProSAT]</span></td></tr>
[[1a2x]] is a 2 chain structure of [[Troponin]] with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A2X OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/TNNC2_RABIT TNNC2_RABIT] Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a2/1a2x_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a2x ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Troponin|Troponin]]
*[[Troponin 3D structures|Troponin 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:009560191</ref><references group="xtra"/>
[[Category: Large Structures]]
[[Category: Oryctolagus cuniculus]]
[[Category: Oryctolagus cuniculus]]
[[Category: Maeda, K.]]
[[Category: Maeda K]]
[[Category: Maeda, Y.]]
[[Category: Maeda Y]]
[[Category: Takeda, S.]]
[[Category: Takeda S]]
[[Category: Vassylyev, D G.]]
[[Category: Vassylyev DG]]
[[Category: Wakatsuki, S.]]
[[Category: Wakatsuki S]]
[[Category: Muscle contraction regulation]]
[[Category: Troponin]]
Retrieved from "https://proteopedia.org/1a2x"