2r8q: Difference between revisions

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[[Image:2r8q.png|left|200px]]


{{STRUCTURE_2r8q|  PDB=2r8q  |  SCENE=  }}
==Structure of LmjPDEB1 in complex with IBMX==
 
<StructureSection load='2r8q' size='340' side='right'caption='[[2r8q]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
===Structure of LmjPDEB1 in complex with IBMX===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2r8q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R8Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R8Q FirstGlance]. <br>
{{ABSTRACT_PUBMED_17944832}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IBM:3-ISOBUTYL-1-METHYLXANTHINE'>IBM</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r8q OCA], [https://pdbe.org/2r8q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r8q RCSB], [https://www.ebi.ac.uk/pdbsum/2r8q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r8q ProSAT]</span></td></tr>
[[2r8q]] is a 2 chain structure of [[Phosphodiesterase]] with sequence from [http://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R8Q OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q6S996_LEIMA Q6S996_LEIMA]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r8/2r8q_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r8q ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Phosphodiesterase|Phosphodiesterase]]
*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:017944832</ref><references group="xtra"/>
[[Category: Large Structures]]
[[Category: 3',5'-cyclic-nucleotide phosphodiesterase]]
[[Category: Leishmania major]]
[[Category: Leishmania major]]
[[Category: Geng, J.]]
[[Category: Geng J]]
[[Category: Ke, H.]]
[[Category: Ke H]]
[[Category: Kunz, S.]]
[[Category: Kunz S]]
[[Category: Seebeck, T.]]
[[Category: Seebeck T]]
[[Category: Wang, H.]]
[[Category: Wang H]]
[[Category: Yan, Z.]]
[[Category: Yan Z]]
[[Category: Camp phosphodiesterase]]
[[Category: Hydrolase]]
[[Category: Leishimaniasis]]
[[Category: Parasite inhibitor selectivity]]

Latest revision as of 09:20, 21 February 2024

Structure of LmjPDEB1 in complex with IBMX

2r8q, resolution 1.50Å

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