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[[Image:1ewn.png|left|200px]]


{{STRUCTURE_1ewn|  PDB=1ewn  |  SCENE=  }}
==CRYSTAL STRUCTURE OF THE HUMAN AAG DNA REPAIR GLYCOSYLASE COMPLEXED WITH 1,N6-ETHENOADENINE-DNA==
 
<StructureSection load='1ewn' size='340' side='right'caption='[[1ewn]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
===CRYSTAL STRUCTURE OF THE HUMAN AAG DNA REPAIR GLYCOSYLASE COMPLEXED WITH 1,N6-ETHENOADENINE-DNA===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1ewn]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EWN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EWN FirstGlance]. <br>
{{ABSTRACT_PUBMED_11106395}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDA:3-[2-DEOXY-RIBOFURANOSYL]-3H-1,3,4,5A,8-PENTAAZA-AS-INDACENE-5-MONOPHOSPHATE'>EDA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ewn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ewn OCA], [https://pdbe.org/1ewn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ewn RCSB], [https://www.ebi.ac.uk/pdbsum/1ewn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ewn ProSAT]</span></td></tr>
[[1ewn]] is a 3 chain structure of [[DNA glycosylate]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EWN OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/3MG_HUMAN 3MG_HUMAN] Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ew/1ewn_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ewn ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[DNA glycosylate|DNA glycosylate]]
*[[DNA glycosylase 3D structures|DNA glycosylase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:011106395</ref><references group="xtra"/>
[[Category: DNA-3-methyladenine glycosylase II]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Ellenberger, T.]]
[[Category: Large Structures]]
[[Category: Glassner, B J.]]
[[Category: Ellenberger T]]
[[Category: Lau, A Y.]]
[[Category: Glassner BJ]]
[[Category: Samson, L D.]]
[[Category: Lau AY]]
[[Category: Wyatt, M D.]]
[[Category: Samson LD]]
[[Category: 3-methyladenine dna glycosylase]]
[[Category: Wyatt MD]]
[[Category: Aag]]
[[Category: Anpg]]
[[Category: Dna repair]]
[[Category: Glycosylase]]
[[Category: Hydrolase-dna complex]]
[[Category: Mpg]]
Retrieved from "https://proteopedia.org/1ewn"