3s53: Difference between revisions

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[[Image:3s53.png|left|200px]]


{{STRUCTURE_3s53|  PDB=3s53  |  SCENE=  }}
==HIV-1 protease triple mutants V32I, I47V, V82I with antiviral drug darunavir in space group P212121==
 
<StructureSection load='3s53' size='340' side='right'caption='[[3s53]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
===HIV-1 protease triple mutants V32I, I47V, V82I with antiviral drug darunavir in space group P212121===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3s53]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S53 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S53 FirstGlance]. <br>
{{ABSTRACT_PUBMED_22238126}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=017:(3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE'>017</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s53 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s53 OCA], [https://pdbe.org/3s53 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s53 RCSB], [https://www.ebi.ac.uk/pdbsum/3s53 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s53 ProSAT]</span></td></tr>
[[3s53]] is a 2 chain structure of [[Virus protease]] with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S53 OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q7SSI0_9HIV1 Q7SSI0_9HIV1]


==See Also==
==See Also==
*[[Virus protease|Virus protease]]
*[[Immunodeficiency virus protease 3D structures|Immunodeficiency virus protease 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:022238126</ref><references group="xtra"/>
[[Category: HIV-1 retropepsin]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Tie, Y F.]]
[[Category: Large Structures]]
[[Category: Wang, Y F.]]
[[Category: Tie Y-F]]
[[Category: Weber, I T.]]
[[Category: Wang Y-F]]
[[Category: Aspartic protease]]
[[Category: Weber IT]]
[[Category: Darunavir]]
[[Category: Drug resistance]]
[[Category: Hiv/aid]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Molecular recognition]]

Latest revision as of 12:46, 14 March 2024

HIV-1 protease triple mutants V32I, I47V, V82I with antiviral drug darunavir in space group P212121

3s53, resolution 1.50Å

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