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[[Image:2dp6.png|left|200px]]


{{STRUCTURE_2dp6|  PDB=2dp6  |  SCENE=  }}
==Crystal structure of uracil-DNA glycosylase in complex with AP:C containing DNA==
 
<StructureSection load='2dp6' size='340' side='right'caption='[[2dp6]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
===Crystal structure of uracil-DNA glycosylase in complex with AP:C containing DNA===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2dp6]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DP6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DP6 FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
==About this Structure==
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2HP:DIHYDROGENPHOSPHATE+ION'>2HP</scene>, <scene name='pdbligand=EOH:ETHANOL'>EOH</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ORP:2-DEOXY-5-PHOSPHONO-RIBOSE'>ORP</scene></td></tr>
[[2dp6]] is a 3 chain structure of [[DNA glycosylate]] with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DP6 OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dp6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dp6 OCA], [https://pdbe.org/2dp6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dp6 RCSB], [https://www.ebi.ac.uk/pdbsum/2dp6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dp6 ProSAT], [https://www.topsan.org/Proteins/RSGI/2dp6 TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/UDGB_THET8 UDGB_THET8] DNA glycosylase with broad substrate specificity. Can remove uracil from double-stranded DNA containing either a U/G, U/A, U/C or U/T base pair (PubMed:12000829, PubMed:17870091, PubMed:24838246). Can also excise hypoxanthine from double-stranded DNA containing G/I, T/I, and A/I base pairs, xanthine from both double-stranded and single stranded DNA, thymine from G/T mismatched DNA, 5'-hydroxymethyluracil and 5'-fluorouracil (PubMed:17870091, PubMed:24838246).<ref>PMID:12000829</ref> <ref>PMID:17870091</ref> <ref>PMID:24838246</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dp/2dp6_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dp6 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[DNA glycosylate|DNA glycosylate]]
*[[DNA glycosylase 3D structures|DNA glycosylase 3D structures]]
[[Category: Thermus thermophilus]]
== References ==
[[Category: Hoseki, J.]]
<references/>
[[Category: Kosaka, H.]]
__TOC__
[[Category: Kuramitsu, S.]]
</StructureSection>
[[Category: Masui, R.]]
[[Category: Large Structures]]
[[Category: Nakagawa, N.]]
[[Category: Thermus thermophilus HB8]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Hoseki J]]
[[Category: Base excision repair]]
[[Category: Kosaka H]]
[[Category: Dna complex]]
[[Category: Kuramitsu S]]
[[Category: Hydrolase-dna complex]]
[[Category: Masui R]]
[[Category: Iron/sulfer cluster]]
[[Category: Nakagawa N]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Riken structural genomics/proteomics initiative]]
[[Category: Rsgi]]
[[Category: Structural genomic]]
[[Category: Thermophile]]
[[Category: Uracil-dna glycosylase]]
Retrieved from "https://proteopedia.org/2dp6"