3pgw: Difference between revisions
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==Crystal structure of human U1 snRNP== | |||
<StructureSection load='3pgw' size='340' side='right'caption='[[3pgw]], [[Resolution|resolution]] 4.40Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3pgw]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PGW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PGW FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.4Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pgw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pgw OCA], [https://pdbe.org/3pgw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pgw RCSB], [https://www.ebi.ac.uk/pdbsum/3pgw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pgw ProSAT]</span></td></tr> | |||
== | </table> | ||
[[3pgw]] is a | == Function == | ||
[https://www.uniprot.org/uniprot/SNRPA_HUMAN SNRPA_HUMAN] Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. Binds preferentially to the 5'-UGCAC-3' motif in vitro.<ref>PMID:9848648</ref> | |||
==See Also== | ==See Also== | ||
*[[Nucleoprotein|Nucleoprotein]] | *[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]] | ||
*[[Sm-like protein 3D structures|Sm-like protein 3D structures]] | |||
== | == References == | ||
< | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Kastner | [[Category: Large Structures]] | ||
[[Category: Luehrmann | [[Category: Kastner B]] | ||
[[Category: Trowitzsch | [[Category: Luehrmann R]] | ||
[[Category: Wahl | [[Category: Trowitzsch S]] | ||
[[Category: Weber | [[Category: Wahl MC]] | ||
[[Category: Weber G]] | |||
Latest revision as of 10:40, 21 February 2024
Crystal structure of human U1 snRNP
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