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[[Image:1th6.png|left|200px]]


{{STRUCTURE_1th6|  PDB=1th6  |  SCENE=  }}
==Crystal structure of phospholipase A2 in complex with atropine at 1.23A resolution==
 
<StructureSection load='1th6' size='340' side='right'caption='[[1th6]], [[Resolution|resolution]] 1.23&Aring;' scene=''>
===Crystal structure of phospholipase A2 in complex with atropine at 1.23A resolution===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1th6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Daboia_russelii_russelii Daboia russelii russelii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TH6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TH6 FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.23&#8491;</td></tr>
==About this Structure==
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OIN:(1R,5S)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL+(2R)-3-HYDROXY-2-PHENYLPROPANOATE'>OIN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
[[1th6]] is a 1 chain structure of [[Phospholipase A2]] with sequence from [http://en.wikipedia.org/wiki/Daboia_russellii_russellii Daboia russellii russellii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TH6 OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1th6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1th6 OCA], [https://pdbe.org/1th6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1th6 RCSB], [https://www.ebi.ac.uk/pdbsum/1th6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1th6 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PA2B8_DABRR PA2B8_DABRR] Snake venom phospholipase A2 (PLA2) that shows weak neurotoxicity and medium anticoagulant effects by binding to factor Xa (F10) and inhibiting the prothrombinase activity (IC(50) is 130 nM) (PubMed:18062812). It also damages vital organs such as lung, liver and kidney, displays edema-inducing activities when injected into the foot pads of mice and induces necrosis of muscle cells when injected into the thigh muscle. Has a low enzymatic activity. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.<ref>PMID:18062812</ref> <ref>PMID:2115497</ref> <ref>PMID:8835338</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/th/1th6_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1th6 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Phospholipase A2|Phospholipase A2]]
*[[Phospholipase A2|Phospholipase A2]]
[[Category: Daboia russellii russellii]]
*[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]]
[[Category: Betzel, C.]]
== References ==
[[Category: Jabeen, T.]]
<references/>
[[Category: Pal, A.]]
__TOC__
[[Category: Perbandt, M.]]
</StructureSection>
[[Category: Sharma, S.]]
[[Category: Daboia russelii russelii]]
[[Category: Singh, N.]]
[[Category: Large Structures]]
[[Category: Singh, T P.]]
[[Category: Betzel C]]
[[Category: Eicosanoid]]
[[Category: Jabeen T]]
[[Category: Hydrolase]]
[[Category: Pal A]]
[[Category: Inhibition]]
[[Category: Perbandt M]]
[[Category: Phospholipid]]
[[Category: Sharma S]]
[[Category: Singh N]]
[[Category: Singh TP]]
Retrieved from "https://proteopedia.org/1th6"