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[[Image:3cc4.png|left|200px]]


{{STRUCTURE_3cc4|  PDB=3cc4  |  SCENE=  }}
==Co-crystal Structure of Anisomycin Bound to the 50S Ribosomal Subunit==
 
<StructureSection load='3cc4' size='340' side='right'caption='[[3cc4]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
===Co-crystal Structure of Anisomycin Bound to the 50S Ribosomal Subunit===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3cc4]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Haloarcula_marismortui Haloarcula marismortui]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CC4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CC4 FirstGlance]. <br>
{{ABSTRACT_PUBMED_18455733}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1MA:6-HYDRO-1-METHYLADENOSINE-5-MONOPHOSPHATE'>1MA</scene>, <scene name='pdbligand=ANM:ANISOMYCIN'>ANM</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=OMG:O2-METHYLGUANOSINE-5-MONOPHOSPHATE'>OMG</scene>, <scene name='pdbligand=OMU:O2-METHYLURIDINE+5-MONOPHOSPHATE'>OMU</scene>, <scene name='pdbligand=PSU:PSEUDOURIDINE-5-MONOPHOSPHATE'>PSU</scene>, <scene name='pdbligand=SR:STRONTIUM+ION'>SR</scene>, <scene name='pdbligand=UR3:3-METHYLURIDINE-5-MONOPHOSHATE'>UR3</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cc4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cc4 OCA], [https://pdbe.org/3cc4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cc4 RCSB], [https://www.ebi.ac.uk/pdbsum/3cc4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cc4 ProSAT]</span></td></tr>
[[3cc4]] is a 30 chain structure of [[Ribosomal protein L10]], [[Ribosomal protein L11]], [[Ribosomal protein L13]], [[Ribosomal protein L14]], [[Ribosomal protein L19]], [[Ribosomal protein L2]], [[Ribosomal protein L21]], [[Ribosomal protein L3]], [[Ribosomal protein L34]], [[Ribosomal protein L4]], [[Ribosomal protein L5]], [[Ribosomal protein L6]], [[Ribosomal protein L7]] and [[Ribosome]] with sequence from [http://en.wikipedia.org/wiki/Haloarcula_marismortui Haloarcula marismortui]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CC4 OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/RL2_HALMA RL2_HALMA] One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome (By similarity).[HAMAP-Rule:MF_01320_A]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cc/3cc4_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cc4 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Ribosomal protein L10|Ribosomal protein L10]]
*[[Ribosome 3D structures|Ribosome 3D structures]]
*[[Ribosomal protein L11|Ribosomal protein L11]]
__TOC__
*[[Ribosomal protein L13|Ribosomal protein L13]]
</StructureSection>
*[[Ribosomal protein L14|Ribosomal protein L14]]
*[[Ribosomal protein L19|Ribosomal protein L19]]
*[[Ribosomal protein L2|Ribosomal protein L2]]
*[[Ribosomal protein L21|Ribosomal protein L21]]
*[[Ribosomal protein L3|Ribosomal protein L3]]
*[[Ribosomal protein L34|Ribosomal protein L34]]
*[[Ribosomal protein L4|Ribosomal protein L4]]
*[[Ribosomal protein L5|Ribosomal protein L5]]
*[[Ribosomal protein L6|Ribosomal protein L6]]
*[[Ribosomal protein L7|Ribosomal protein L7]]
*[[Ribosome|Ribosome]]
 
==Reference==
<ref group="xtra">PMID:018455733</ref><ref group="xtra">PMID:012860128</ref><references group="xtra"/>
[[Category: Haloarcula marismortui]]
[[Category: Blaha, G.]]
[[Category: Gurel, G.]]
[[Category: Anisomycin]]
[[Category: Co-crystal]]
[[Category: Haloarcula marismortui]]
[[Category: Haloarcula marismortui]]
[[Category: Large ribosomal subunit]]
[[Category: Large Structures]]
[[Category: Ribosome]]
[[Category: Blaha G]]
[[Category: Wild type]]
[[Category: Gurel G]]

Latest revision as of 09:34, 21 February 2024

Co-crystal Structure of Anisomycin Bound to the 50S Ribosomal Subunit

3cc4, resolution 2.70Å

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