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[[Image:1u58.png|left|200px]]


{{STRUCTURE_1u58| PDB=1u58 | SCENE= }}
==Crystal structure of the murine cytomegalovirus MHC-I homolog m144==
<StructureSection load='1u58' size='340' side='right'caption='[[1u58]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1u58]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Murid_betaherpesvirus_1 Murid betaherpesvirus 1] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U58 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U58 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u58 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u58 OCA], [https://pdbe.org/1u58 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u58 RCSB], [https://www.ebi.ac.uk/pdbsum/1u58 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u58 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A2Q6L5_MUHVK A2Q6L5_MUHVK]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u5/1u58_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u58 ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Large DNA viruses of the herpesvirus family produce proteins that mimic host MHC-I molecules as part of their immunoevasive strategy. The m144 glycoprotein, expressed by murine cytomegalovirus, is thought to be an MHC-I homolog whose expression prolongs viral survival in vivo by preventing natural killer cell activation. To explore the structural basis of this m144 function, we have determined the three-dimensional structure of an m144/beta2-microglobulin (beta2m) complex at 1.9A resolution. This structure reveals the canonical features of MHC-I molecules including readily identifiable alpha1, alpha2, and alpha3 domains. A unique disulfide bond links the alpha1 helix to the beta-sheet floor, explaining the known thermal stability of m144. Close juxtaposition of the alpha1 and alpha2 helices and the lack of critical residues that normally contribute to anchoring the peptide N and C termini eliminates peptide binding. A region of 13 amino acid residues, corresponding to the amino-terminal portion of the alpha2 helix, is missing in the electron density map, suggesting an area of structural flexibility that may be involved in ligand binding.


===Crystal structure of the murine cytomegalovirus MHC-I homolog m144===
Crystal structure of the murine cytomegalovirus MHC-I homolog m144.,Natarajan K, Hicks A, Mans J, Robinson H, Guan R, Mariuzza RA, Margulies DH J Mol Biol. 2006 Apr 21;358(1):157-71. Epub 2006 Feb 9. PMID:16500675<ref>PMID:16500675</ref>


{{ABSTRACT_PUBMED_16500675}}
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
==About this Structure==
<div class="pdbe-citations 1u58" style="background-color:#fffaf0;"></div>
[[1u58]] is a 2 chain structure of [[Beta-2 microglobulin]] with sequence from [http://en.wikipedia.org/wiki/Murid_herpesvirus_1 Murid herpesvirus 1] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U58 OCA].


==See Also==
==See Also==
*[[Beta-2 microglobulin|Beta-2 microglobulin]]
*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:016500675</ref><references group="xtra"/>
__TOC__
[[Category: Murid herpesvirus 1]]
</StructureSection>
[[Category: Large Structures]]
[[Category: Murid betaherpesvirus 1]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Guan, R.]]
[[Category: Guan R]]
[[Category: Hicks, A.]]
[[Category: Hicks A]]
[[Category: Margulies, D H.]]
[[Category: Margulies DH]]
[[Category: Natarajan, K.]]
[[Category: Natarajan K]]
[[Category: Robinson, H.]]
[[Category: Robinson H]]
[[Category: Beta-2m]]
[[Category: Immune system]]
[[Category: M144]]
[[Category: Mcmv]]
[[Category: Mhc-i homolog]]
Retrieved from "https://proteopedia.org/1u58"