2ztj: Difference between revisions

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[[Image:2ztj.png|left|200px]]


{{STRUCTURE_2ztj|  PDB=2ztj  |  SCENE=  }}
==Crystal structure of homocitrate synthase from Thermus thermophilus complexed with alpha-ketoglutarate==
 
<StructureSection load='2ztj' size='340' side='right'caption='[[2ztj]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
===Crystal structure of homocitrate synthase from Thermus thermophilus complexed with alpha-ketoglutarate===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2ztj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB27 Thermus thermophilus HB27]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZTJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZTJ FirstGlance]. <br>
{{ABSTRACT_PUBMED_19996101}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ztj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ztj OCA], [https://pdbe.org/2ztj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ztj RCSB], [https://www.ebi.ac.uk/pdbsum/2ztj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ztj ProSAT]</span></td></tr>
[[2ztj]] is a 1 chain structure of [[Homocitrate synthase]] with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZTJ OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/HOSA_THET2 HOSA_THET2] Catalyzes the aldol-type condensation of 2-oxoglutarate with acetyl-CoA to yield homocitrate (PubMed:19996101, PubMed:12095615). Carries out the first step of the alpha-aminoadipate (AAA) lysine biosynthesis pathway (PubMed:9868782). To a lesser extent, can also use oxaloacetate in place of 2-oxoglutarate, leading to citrate. Does not display 2-isopropylmalate synthase activity since it cannot use 2-oxoisovalerate (PubMed:12095615).<ref>PMID:12095615</ref> <ref>PMID:19996101</ref> <ref>PMID:9868782</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zt/2ztj_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ztj ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Homocitrate synthase|Homocitrate synthase]]
*[[Homocitrate synthase|Homocitrate synthase]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:019996101</ref><references group="xtra"/>
__TOC__
[[Category: Homocitrate synthase]]
</StructureSection>
[[Category: Thermus thermophilus]]
[[Category: Large Structures]]
[[Category: Kuzuyama, T.]]
[[Category: Thermus thermophilus HB27]]
[[Category: Nishiyama, M.]]
[[Category: Kuzuyama T]]
[[Category: Okada, T.]]
[[Category: Nishiyama M]]
[[Category: Tomita, T.]]
[[Category: Okada T]]
[[Category: Amino-acid biosynthesis]]
[[Category: Tomita T]]
[[Category: Lysine biosynthesis]]
[[Category: Substrate complex]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/2ztj"