2hqp: Difference between revisions

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[[Image:2hqp.png|left|200px]]


{{STRUCTURE_2hqp|  PDB=2hqp  |  SCENE=  }}
==Solution structure of L.casei dihydrofolate reductase complexed with NADPH, 32 structures==
 
<StructureSection load='2hqp' size='340' side='right'caption='[[2hqp]]' scene=''>
===Solution structure of L.casei dihydrofolate reductase complexed with NADPH, 32 structures===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2hqp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lacticaseibacillus_casei Lacticaseibacillus casei]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HQP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HQP FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
==About this Structure==
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
[[2hqp]] is a 1 chain structure of [[Dihydrofolate reductase]] with sequence from [http://en.wikipedia.org/wiki/Lactobacillus_casei Lactobacillus casei]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HQP OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hqp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hqp OCA], [https://pdbe.org/2hqp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hqp RCSB], [https://www.ebi.ac.uk/pdbsum/2hqp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hqp ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DYR_LACCA DYR_LACCA] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hq/2hqp_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hqp ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Dihydrofolate reductase|Dihydrofolate reductase]]
*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
[[Category: Dihydrofolate reductase]]
__TOC__
[[Category: Lactobacillus casei]]
</StructureSection>
[[Category: Birdsall, B.]]
[[Category: Lacticaseibacillus casei]]
[[Category: Polshakov, V I.]]
[[Category: Large Structures]]
[[Category: Dhfr]]
[[Category: Birdsall B]]
[[Category: Oxidoreductase]]
[[Category: Polshakov VI]]

Latest revision as of 19:02, 29 May 2024

Solution structure of L.casei dihydrofolate reductase complexed with NADPH, 32 structures

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