1ob8: Difference between revisions

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[[Image:1ob8.png|left|200px]]


{{STRUCTURE_1ob8|  PDB=1ob8  |  SCENE= }}
==Holliday Junction Resolving Enzyme==
 
<StructureSection load='1ob8' size='340' side='right'caption='[[1ob8]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
===HOLLIDAY JUNCTION RESOLVING ENZYME===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1ob8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus Saccharolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OB8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OB8 FirstGlance]. <br>
{{ABSTRACT_PUBMED_15479781}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ob8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ob8 OCA], [https://pdbe.org/1ob8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ob8 RCSB], [https://www.ebi.ac.uk/pdbsum/1ob8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ob8 ProSAT]</span></td></tr>
[[1ob8]] is a 2 chain structure of [[Resolvase]] with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OB8 OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/HJE_SACS2 HJE_SACS2] A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Acts only on 4-way DNA junctions in a sequence non-specific manner; introduces paired nicks in opposing strands 2 bases 3' of the point of strand exchange only on continuous strands of 4-way junction DNA. Cleaves both mobile and immobile junctions.<ref>PMID:10623519</ref> <ref>PMID:10736227</ref> <ref>PMID:15921693</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ob/1ob8_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ob8 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Resolvase|Resolvase]]
*[[Resolvase 3D structures|Resolvase 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:015479781</ref><references group="xtra"/>
__TOC__
[[Category: Sulfolobus solfataricus]]
</StructureSection>
[[Category: Bond, C S.]]
[[Category: Large Structures]]
[[Category: Middleton, C L.]]
[[Category: Saccharolobus solfataricus]]
[[Category: Parker, J L.]]
[[Category: Bond CS]]
[[Category: Richard, D J.]]
[[Category: Middleton CL]]
[[Category: White, M F.]]
[[Category: Parker JL]]
[[Category: Archaea]]
[[Category: Richard DJ]]
[[Category: Enzyme]]
[[Category: White MF]]
[[Category: Holliday junction resolving enzyme]]
[[Category: Homologous recombination]]
[[Category: Hydrolase]]
[[Category: Nuclease]]
[[Category: Thermophile]]
Retrieved from "https://proteopedia.org/1ob8"