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[[Image:1fe6.jpg|left|200px]]<br /><applet load="1fe6" size="350" color="white" frame="true" align="right" spinBox="true"
caption="1fe6, resolution 1.80&Aring;" />
'''CRYSTAL STRUCTURE OF A NATURALLY OCCURING PARALLEL RIGHT-HANDED COILED-COIL TETRAMER'''<br />


==Overview==
==CRYSTAL STRUCTURE OF A NATURALLY OCCURING PARALLEL RIGHT-HANDED COILED-COIL TETRAMER==
The crystal structure of a polypeptide chain fragment from the surface layer protein tetrabrachion from Staphylothermus marinus has been determined at 1.8 A resolution. As proposed on the basis of the presence of 11-residue repeats, the polypeptide chain fragment forms a parallel right-handed coiled coil structure. Complementary hydrophobic interactions and complex networks of surface salt bridges result in an extremely thermostable tetrameric structure with remarkable properties. In marked contrast to left-handed coiled coil tetramers, the right-handed coiled coil reveals large hydrophobic cavities that are filled with water molecules. As a consequence, the packing of the hydrophobic core differs markedly from that of a right-handed parallel coiled coil tetramer that was designed on the basis of left-handed coiled coil structures.
<StructureSection load='1fe6' size='340' side='right'caption='[[1fe6]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[1fe6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylothermus_marinus Staphylothermus marinus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FE6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FE6 FirstGlance]. <br>
1FE6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Staphylothermus_marinus Staphylothermus marinus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FE6 OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fe6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fe6 OCA], [https://pdbe.org/1fe6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fe6 RCSB], [https://www.ebi.ac.uk/pdbsum/1fe6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fe6 ProSAT]</span></td></tr>
==Reference==
</table>
Crystal structure of a naturally occurring parallel right-handed coiled coil tetramer., Stetefeld J, Jenny M, Schulthess T, Landwehr R, Engel J, Kammerer RA, Nat Struct Biol. 2000 Sep;7(9):772-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10966648 10966648]
== Function ==
[[Category: Single protein]]
[https://www.uniprot.org/uniprot/Q54436_STAMA Q54436_STAMA]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Staphylothermus marinus]]
[[Category: Staphylothermus marinus]]
[[Category: Stetefeld, J.]]
[[Category: Stetefeld J]]
[[Category: right handed coiled coil]]
 
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