1ff4: Difference between revisions

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[[Image:1ff4.gif|left|200px]]<br /><applet load="1ff4" size="350" color="white" frame="true" align="right" spinBox="true"
caption="1ff4, resolution 1.50&Aring;" />
'''X-RAY STRUCTURE OF MUSCARINIC TOXIN 2 AT 1.5 ANGSTROM RESOLUTION'''<br />


==About this Structure==
==X-RAY STRUCTURE OF MUSCARINIC TOXIN 2 AT 1.5 ANGSTROM RESOLUTION==
1FF4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Dendroaspis_angusticeps Dendroaspis angusticeps] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FF4 OCA].  
<StructureSection load='1ff4' size='340' side='right'caption='[[1ff4]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1ff4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dendroaspis_angusticeps Dendroaspis angusticeps]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FF4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FF4 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ff4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ff4 OCA], [https://pdbe.org/1ff4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ff4 RCSB], [https://www.ebi.ac.uk/pdbsum/1ff4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ff4 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/3SIM2_DENAN 3SIM2_DENAN] Binds irreversibly to M1 (CHRM1) muscarinic acetylcholine receptors, and reveals a slightly weaker effect on M3 (CHRM3) receptors. The mechanism of toxin-receptor interaction comprises at least two steps. The first step is fast with no competition between the toxin and the antagonist. The second step is slow with formation of a more stable toxin-receptor complex and inhibition of the antagonist binding.<ref>PMID:7778123</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ff/1ff4_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ff4 ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Dendroaspis angusticeps]]
[[Category: Dendroaspis angusticeps]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Du, M H.Le.]]
[[Category: Gaucher JF]]
[[Category: Gaucher, J F.]]
[[Category: Le Du MH]]
[[Category: Menez, A.]]
[[Category: Menez A]]
[[Category: Menez, R.]]
[[Category: Menez R]]
[[Category: SO4]]
[[Category: three fingers motif]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:37:57 2008''
Retrieved from "https://proteopedia.org/1ff4"