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[[Image:2tec.png|left|200px]]


{{STRUCTURE_2tec|  PDB=2tec  |  SCENE=  }}
==MOLECULAR DYNAMICS REFINEMENT OF A THERMITASE-EGLIN-C COMPLEX AT 1.98 ANGSTROMS RESOLUTION AND COMPARISON OF TWO CRYSTAL FORMS THAT DIFFER IN CALCIUM CONTENT==
 
<StructureSection load='2tec' size='340' side='right'caption='[[2tec]], [[Resolution|resolution]] 1.98&Aring;' scene=''>
===MOLECULAR DYNAMICS REFINEMENT OF A THERMITASE-EGLIN-C COMPLEX AT 1.98 ANGSTROMS RESOLUTION AND COMPARISON OF TWO CRYSTAL FORMS THAT DIFFER IN CALCIUM CONTENT===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2tec]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Poecilobdella_manillensis Poecilobdella manillensis] and [https://en.wikipedia.org/wiki/Thermoactinomyces_vulgaris Thermoactinomyces vulgaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2TEC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2TEC FirstGlance]. <br>
{{ABSTRACT_PUBMED_2689655}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.98&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2tec FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2tec OCA], [https://pdbe.org/2tec PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2tec RCSB], [https://www.ebi.ac.uk/pdbsum/2tec PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2tec ProSAT]</span></td></tr>
[[2tec]] is a 2 chain structure of [[Eglin]] with sequence from [http://en.wikipedia.org/wiki/Hirudinaria_manillensis Hirudinaria manillensis] and [http://en.wikipedia.org/wiki/Thermoactinomyces_vulgaris Thermoactinomyces vulgaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2TEC OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/ICIC_HIRME ICIC_HIRME] Inhibits both elastase and cathepsin G.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/te/2tec_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2tec ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Eglin|Eglin]]
*[[Eglin|Eglin]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:002689655</ref><ref group="xtra">PMID:007770448</ref><references group="xtra"/>
[[Category: Large Structures]]
[[Category: Hirudinaria manillensis]]
[[Category: Poecilobdella manillensis]]
[[Category: Thermitase]]
[[Category: Thermoactinomyces vulgaris]]
[[Category: Thermoactinomyces vulgaris]]
[[Category: Betzel, C.]]
[[Category: Betzel C]]
[[Category: Dauter, Z.]]
[[Category: Dauter Z]]
[[Category: Gros, P.]]
[[Category: Gros P]]
[[Category: Hol, W G.J.]]
[[Category: Hol WGJ]]
[[Category: Wilson, K S.]]
[[Category: Wilson KS]]
Retrieved from "https://proteopedia.org/2tec"