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[[Image:2kb0.png|left|200px]]


{{STRUCTURE_2kb0|  PDB=2kb0  |  SCENE=  }}
==Cdc42(T35A)==
 
<StructureSection load='2kb0' size='340' side='right'caption='[[2kb0]]' scene=''>
===Cdc42(T35A)===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2kb0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KB0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KB0 FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kb0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kb0 OCA], [https://pdbe.org/2kb0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kb0 RCSB], [https://www.ebi.ac.uk/pdbsum/2kb0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kb0 ProSAT]</span></td></tr>
[[2kb0]] is a 1 chain structure of [[GTP-binding protein]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KB0 OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/CDC42_HUMAN CDC42_HUMAN] Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration.<ref>PMID:14978216</ref> <ref>PMID:15642749</ref> <ref>PMID:17038317</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kb/2kb0_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kb0 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[GTP-binding protein|GTP-binding protein]]
*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Adams, P D.]]
[[Category: Large Structures]]
[[Category: McFeeters, R.]]
[[Category: Adams PD]]
[[Category: Oswald, R E.]]
[[Category: McFeeters R]]
[[Category: Cell membrane]]
[[Category: Oswald RE]]
[[Category: Folded]]
[[Category: Globular]]
[[Category: Gtp-binding]]
[[Category: Lipoprotein]]
[[Category: Membrane]]
[[Category: Methylation]]
[[Category: Mutation]]
[[Category: Nucleotide-binding]]
[[Category: Prenylation]]
[[Category: Ra]]
[[Category: Signaling protein]]
[[Category: Switch 1]]
Retrieved from "https://proteopedia.org/2kb0"