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[[Image:2d2w.png|left|200px]]


{{STRUCTURE_2d2w|  PDB=2d2w  |  SCENE=  }}
==Solution structure and Dynamics of the DNA-Binding Domain of Myocyte Nuclear Factor==
 
<StructureSection load='2d2w' size='340' side='right'caption='[[2d2w]]' scene=''>
===Solution structure and Dynamics of the DNA-Binding Domain of Myocyte Nuclear Factor===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2d2w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D2W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2D2W FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d2w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d2w OCA], [https://pdbe.org/2d2w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d2w RCSB], [https://www.ebi.ac.uk/pdbsum/2d2w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d2w ProSAT]</span></td></tr>
[[2d2w]] is a 1 chain structure of [[Forkhead box protein]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D2W OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/FOXK1_MOUSE FOXK1_MOUSE] Transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin gene. Has a role in myogenic differentiation and in remodeling processes of adult muscles that occur in response to physiological stimuli.<ref>PMID:8007964</ref> <ref>PMID:9271401</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d2/2d2w_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2d2w ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Forkhead box protein|Forkhead box protein]]
*[[FOX 3D structures|FOX 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Chang, C H.]]
[[Category: Chang C-H]]
[[Category: Chu, Y P.]]
[[Category: Chu Y-P]]
[[Category: Chuang, W J.]]
[[Category: Chuang W-J]]
[[Category: Jeng, W Y.]]
[[Category: Jeng W-Y]]
[[Category: Dna binding protein]]
[[Category: Dna-binding domain]]
[[Category: Forkhead]]
[[Category: Winged-helix]]
Retrieved from "https://proteopedia.org/2d2w"