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[[Image:3ior.png|left|200px]]


{{STRUCTURE_3ior|  PDB=3ior  |  SCENE=  }}
==Huntingtin amino-terminal region with 17 Gln residues - crystal C95==
 
<StructureSection load='3ior' size='340' side='right'caption='[[3ior]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
===Huntingtin amino-terminal region with 17 Gln residues - crystal C95===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3ior]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IOR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IOR FirstGlance]. <br>
{{ABSTRACT_PUBMED_19748341}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.6&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ior FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ior OCA], [https://pdbe.org/3ior PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ior RCSB], [https://www.ebi.ac.uk/pdbsum/3ior PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ior ProSAT]</span></td></tr>
[[3ior]] is a 3 chain structure of [[Maltose-binding protein]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12,_homo_sapiens Escherichia coli k-12, homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IOR OCA].  
</table>
== Disease ==
[https://www.uniprot.org/uniprot/HD_HUMAN HD_HUMAN] Juvenile Huntington disease;Huntington disease. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.[https://www.uniprot.org/uniprot/HD_HUMAN HD_HUMAN] May play a role in microtubule-mediated transport or vesicle function.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/io/3ior_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ior ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Maltose-binding protein|Maltose-binding protein]]
*[[Huntingtin|Huntingtin]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:019748341</ref><references group="xtra"/>
[[Category: Escherichia coli K-12]]
[[Category: Escherichia coli k-12, homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Kim, M W.]]
[[Category: Large Structures]]
[[Category: Apoptosis]]
[[Category: Kim MW]]
[[Category: Disease mutation]]
[[Category: Hd]]
[[Category: Htt-ex1]]
[[Category: Huntingtin]]
[[Category: Nucleus]]
[[Category: Phosphoprotein]]
[[Category: Signaling protein]]
[[Category: Sugar transport]]
[[Category: Transport]]
Retrieved from "https://proteopedia.org/3ior"