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[[Image:3egt.png|left|200px]]


{{STRUCTURE_3egt|  PDB=3egt  |  SCENE=  }}
==T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-722==
 
<StructureSection load='3egt' size='340' side='right'caption='[[3egt]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
===T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-722===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3egt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EGT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EGT FirstGlance]. <br>
{{ABSTRACT_PUBMED_19309137}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=722:1-(2,2-DIPHOSPHONOETHYL)-3-(HEPTYLOXY)PYRIDINIUM'>722</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3egt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3egt OCA], [https://pdbe.org/3egt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3egt RCSB], [https://www.ebi.ac.uk/pdbsum/3egt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3egt ProSAT]</span></td></tr>
[[3egt]] is a 2 chain structure of [[Farnesyl diphosphate synthase]] with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EGT OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q86C09_9TRYP Q86C09_9TRYP]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eg/3egt_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3egt ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Farnesyl diphosphate synthase|Farnesyl diphosphate synthase]]
*[[Farnesyl diphosphate synthase 3D structures|Farnesyl diphosphate synthase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:019309137</ref><references group="xtra"/>
[[Category: Large Structures]]
[[Category: Geranyltranstransferase]]
[[Category: Trypanosoma brucei]]
[[Category: Trypanosoma brucei]]
[[Category: Cao, R.]]
[[Category: Cao R]]
[[Category: Gao, Y.]]
[[Category: Gao Y]]
[[Category: Oldfield, E.]]
[[Category: Oldfield E]]
[[Category: Robinson, H.]]
[[Category: Robinson H]]
[[Category: Isoprene biosynthesis]]
[[Category: Protein-bisphosphonate complex]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/3egt"