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[[Image:3rbl.png|left|200px]]


{{STRUCTURE_3rbl|  PDB=3rbl  |  SCENE=  }}
==Crystal structure of Human aromatic L-amino acid decarboxylase (AADC) in the apo form==
 
<StructureSection load='3rbl' size='340' side='right'caption='[[3rbl]], [[Resolution|resolution]] 3.24&Aring;' scene=''>
===Crystal structure of Human aromatic L-amino acid decarboxylase (AADC) in the apo form===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3rbl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RBL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RBL FirstGlance]. <br>
{{ABSTRACT_PUBMED_22143761}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.24&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rbl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rbl OCA], [https://pdbe.org/3rbl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rbl RCSB], [https://www.ebi.ac.uk/pdbsum/3rbl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rbl ProSAT]</span></td></tr>
[[3rbl]] is a 2 chain structure of [[DOPA decarboxylase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RBL OCA].  
</table>
== Disease ==
[https://www.uniprot.org/uniprot/DDC_HUMAN DDC_HUMAN] Aromatic L-amino acid decarboxylase deficiency. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/DDC_HUMAN DDC_HUMAN] Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.


==See Also==
==See Also==
*[[DOPA decarboxylase|DOPA decarboxylase]]
*[[DOPA decarboxylase|DOPA decarboxylase]]
*[[User:Brian Hernandez/DOPA Decarboxylase|User:Brian Hernandez/DOPA Decarboxylase]]
__TOC__
 
</StructureSection>
==Reference==
<ref group="xtra">PMID:022143761</ref><references group="xtra"/>
[[Category: Aromatic-L-amino-acid decarboxylase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Cellini, B.]]
[[Category: Large Structures]]
[[Category: Cutruzzola, F.]]
[[Category: Borri Voltattorni C]]
[[Category: Gianni, S.]]
[[Category: Cellini B]]
[[Category: Giardina, G.]]
[[Category: Cutruzzola F]]
[[Category: Montioli, R.]]
[[Category: Gianni S]]
[[Category: Paiardini, A.]]
[[Category: Giardina G]]
[[Category: Voltattorni, C Borri.]]
[[Category: Montioli R]]
[[Category: Aadc deficiency]]
[[Category: Paiardini A]]
[[Category: Apo enzyme]]
[[Category: Apo form]]
[[Category: Conformational change]]
[[Category: Ddc]]
[[Category: Decarboxylase]]
[[Category: Exposed]]
[[Category: L-dopa]]
[[Category: Lyase]]
[[Category: Open conformation]]
[[Category: Open dimer]]
[[Category: Parkinson]]
[[Category: Plp]]
Retrieved from "https://proteopedia.org/3rbl"