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[[Image:2ywf.png|left|200px]]


{{STRUCTURE_2ywf|  PDB=2ywf  |  SCENE=  }}
==Crystal structure of GMPPNP-bound LepA from Aquifex aeolicus==
 
<StructureSection load='2ywf' size='340' side='right'caption='[[2ywf]], [[Resolution|resolution]] 2.24&Aring;' scene=''>
===Crystal structure of GMPPNP-bound LepA from Aquifex aeolicus===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2ywf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aquifex_aeolicus_VF5 Aquifex aeolicus VF5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YWF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YWF FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.24&#8491;</td></tr>
==About this Structure==
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
[[2ywf]] is a 1 chain structure of [[GTP-binding protein]] with sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YWF OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ywf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ywf OCA], [https://pdbe.org/2ywf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ywf RCSB], [https://www.ebi.ac.uk/pdbsum/2ywf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ywf ProSAT], [https://www.topsan.org/Proteins/RSGI/2ywf TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LEPA_AQUAE LEPA_AQUAE] Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yw/2ywf_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ywf ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[GTP-binding protein|GTP-binding protein]]
*[[Elongation factor 3D structures|Elongation factor 3D structures]]
[[Category: Aquifex aeolicus]]
*[[Escherichia coli LepA%2C the ribosomal back translocase|Escherichia coli LepA%2C the ribosomal back translocase]]
[[Category: Hanawa-Suetsugu, K.]]
*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
[[Category: Kaminishi, T.]]
__TOC__
[[Category: Kawazoe, M.]]
</StructureSection>
[[Category: Nakayama-Ushikoshi, R.]]
[[Category: Aquifex aeolicus VF5]]
[[Category: Nishino, A.]]
[[Category: Large Structures]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Hanawa-Suetsugu K]]
[[Category: Shirouzu, M.]]
[[Category: Kaminishi T]]
[[Category: Takemoto, C.]]
[[Category: Kawazoe M]]
[[Category: Terada, T.]]
[[Category: Nakayama-Ushikoshi R]]
[[Category: Yokoyama, S.]]
[[Category: Nishino A]]
[[Category: Beta-barrel]]
[[Category: Shirouzu M]]
[[Category: Ferredoxin-like domain]]
[[Category: Takemoto C]]
[[Category: G domain]]
[[Category: Terada T]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Yokoyama S]]
[[Category: Nppsfa]]
[[Category: Riken structural genomics/proteomics initiative]]
[[Category: Rsgi]]
[[Category: Structural genomic]]
[[Category: Translation]]
Retrieved from "https://proteopedia.org/2ywf"