2d4a: Difference between revisions

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[[Image:2d4a.png|left|200px]]


{{STRUCTURE_2d4a|  PDB=2d4a  |  SCENE=  }}
==Structure of the malate dehydrogenase from Aeropyrum pernix==
 
<StructureSection load='2d4a' size='340' side='right'caption='[[2d4a]], [[Resolution|resolution]] 2.87&Aring;' scene=''>
===Structure of the malate dehydrogenase from Aeropyrum pernix===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2d4a]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Aeropyrum_pernix Aeropyrum pernix]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D4A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2D4A FirstGlance]. <br>
{{ABSTRACT_PUBMED_19555779}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.87&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d4a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d4a OCA], [https://pdbe.org/2d4a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d4a RCSB], [https://www.ebi.ac.uk/pdbsum/2d4a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d4a ProSAT]</span></td></tr>
==About this Structure==
</table>
[[2d4a]] is a 4 chain structure of [[Johnson sandbox 1]] and [[Malate dehydrogenase]] with sequence from [http://en.wikipedia.org/wiki/Aeropyrum_pernix Aeropyrum pernix]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D4A OCA].  
== Function ==
[https://www.uniprot.org/uniprot/MDH_AERPE MDH_AERPE] Catalyzes the reversible oxidation of malate to oxaloacetate. Can also oxidize tartrate. Can utilize both NAD and NADP. Has a preference for NADP.<ref>PMID:19555779</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d4/2d4a_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2d4a ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Johnson sandbox 1|Johnson sandbox 1]]
*[[Malate Dehydrogenase 3D structures|Malate Dehydrogenase 3D structures]]
*[[Malate dehydrogenase|Malate dehydrogenase]]
== References ==
 
<references/>
==Reference==
__TOC__
<ref group="xtra">PMID:019555779</ref><references group="xtra"/>
</StructureSection>
[[Category: Aeropyrum pernix]]
[[Category: Aeropyrum pernix]]
[[Category: Malate dehydrogenase]]
[[Category: Large Structures]]
[[Category: Kawakami, R.]]
[[Category: Kawakami R]]
[[Category: Ohshima, T.]]
[[Category: Ohshima T]]
[[Category: Sakuraba, H.]]
[[Category: Sakuraba H]]
[[Category: Tsuge, H.]]
[[Category: Tsuge H]]
[[Category: Archaea]]
[[Category: Hyperthermophile]]
[[Category: Malate dehydrogenase]]
[[Category: Oxidoreductase]]