3san: Difference between revisions
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==Crystal structure of influenza A virus neuraminidase N5 complexed with Zanamivir== | |||
<StructureSection load='3san' size='340' side='right'caption='[[3san]], [[Resolution|resolution]] 1.60Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3san]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/duck/Alberta/60/1976(H12N5)) Influenza A virus (A/duck/Alberta/60/1976(H12N5))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SAN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SAN FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZMR:ZANAMIVIR'>ZMR</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3san FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3san OCA], [https://pdbe.org/3san PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3san RCSB], [https://www.ebi.ac.uk/pdbsum/3san PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3san ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/A1ILL9_I76A2 A1ILL9_I76A2] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
There are 9 serotypes of neuraminidase (NA) from influenza A virus (N1 to N9), which are classified into two groups based on primary sequences (groups 1 and 2). The structural hallmark of the two groups is the presence or absence of an extra 150-cavity (formed by the 150-loop) in the active site. Thus far, structures of NAs from 6 out of the 9 serotypes have been solved. Here, we solved the N5 structure, the last unknown structure group 1 serotype with a unique Asn147 residue in its 150-loop, demonstrating that it has an extended 150-cavity that closes upon inhibitor binding. | |||
Influenza a virus n5 neuraminidase has an extended 150-cavity.,Wang M, Qi J, Liu Y, Vavricka CJ, Wu Y, Li Q, Gao GF J Virol. 2011 Aug;85(16):8431-5. Epub 2011 Jun 8. PMID:21653672<ref>PMID:21653672</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 3san" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
*[[Neuraminidase|Neuraminidase]] | *[[Neuraminidase 3D structures|Neuraminidase 3D structures]] | ||
== References == | |||
== | <references/> | ||
< | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: Large Structures]] | |||
[[Category: Gao | [[Category: Gao GF]] | ||
[[Category: Li | [[Category: Li Q]] | ||
[[Category: Liu | [[Category: Liu Y]] | ||
[[Category: Qi | [[Category: Qi JX]] | ||
[[Category: Vavricka | [[Category: Vavricka CJ]] | ||
[[Category: Wang | [[Category: Wang MY]] | ||
[[Category: Wu | [[Category: Wu Y]] | ||
Latest revision as of 17:24, 1 November 2023
Crystal structure of influenza A virus neuraminidase N5 complexed with Zanamivir
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