3t5i: Difference between revisions

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[[Image:3t5i.png|left|200px]]


{{STRUCTURE_3t5i|  PDB=3t5i  |  SCENE=  }}
==Structure of Fully modified farnesylated Rheb Peptide in complex with PDE6D==
 
<StructureSection load='3t5i' size='340' side='right'caption='[[3t5i]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
===Structure of Fully modified farnesylated Rheb Peptide in complex with PDE6D===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3t5i]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T5I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T5I FirstGlance]. <br>
{{ABSTRACT_PUBMED_22002721}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CMT:O-METHYLCYSTEINE'>CMT</scene>, <scene name='pdbligand=FAR:FARNESYL'>FAR</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t5i OCA], [https://pdbe.org/3t5i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t5i RCSB], [https://www.ebi.ac.uk/pdbsum/3t5i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t5i ProSAT]</span></td></tr>
[[3t5i]] is a 6 chain structure of [[Phosphodiesterase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T5I OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/PDE6D_HUMAN PDE6D_HUMAN] Acts as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude and does so by decreasing the nucleotide dissociation rate. Stabilizes Arl3-GTP by decreasing the nucleotide dissociation (By similarity).


==See Also==
==See Also==
*[[Phosphodiesterase|Phosphodiesterase]]
*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:022002721</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Chen, Y X.]]
[[Category: Large Structures]]
[[Category: Ismail, S A.]]
[[Category: Chen Y-X]]
[[Category: Wittinghofer, A.]]
[[Category: Ismail SA]]
[[Category: Farnesyl]]
[[Category: Wittinghofer A]]
[[Category: Immunoglobulin-like beta sandwitch fold]]
[[Category: Lipid binding protein]]
[[Category: Prenyl]]
[[Category: Rheb]]
[[Category: Signaling protein]]
Retrieved from "https://proteopedia.org/3t5i"