2wiz: Difference between revisions
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==Crystal structures of Holliday junction resolvases from Archaeoglobus fulgidus bound to DNA substrate== | |||
<StructureSection load='2wiz' size='340' side='right'caption='[[2wiz]], [[Resolution|resolution]] 3.30Å' scene=''> | |||
=== | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2wiz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Archaeoglobus_fulgidus_DSM_4304 Archaeoglobus fulgidus DSM 4304] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WIZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WIZ FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3Å</td></tr> | |||
== | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wiz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wiz OCA], [https://pdbe.org/2wiz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wiz RCSB], [https://www.ebi.ac.uk/pdbsum/2wiz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wiz ProSAT]</span></td></tr> | ||
[[2wiz]] is a 4 chain structure | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/HJC_ARCFU HJC_ARCFU] A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.[HAMAP-Rule:MF_01490] | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wi/2wiz_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wiz ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | ==See Also== | ||
*[[Resolvase|Resolvase]] | *[[Resolvase 3D structures|Resolvase 3D structures]] | ||
[[Category: Archaeoglobus fulgidus]] | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Archaeoglobus fulgidus DSM 4304]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Synthetic construct]] | ||
[[Category: | [[Category: Basquin J]] | ||
[[Category: | [[Category: Carolis C]] | ||
[[Category: | [[Category: Koehler C]] | ||
[[Category: | [[Category: Sauter C]] | ||
[[Category: Suck D]] | |||
[[Category: Toeroe I]] | |||
Latest revision as of 15:59, 13 December 2023
Crystal structures of Holliday junction resolvases from Archaeoglobus fulgidus bound to DNA substrate
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