3bsu: Difference between revisions

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[[Image:3bsu.png|left|200px]]


{{STRUCTURE_3bsu|  PDB=3bsu  |  SCENE=  }}
==Hybrid-binding domain of human RNase H1 in complex with 12-mer RNA/DNA==
 
<StructureSection load='3bsu' size='340' side='right'caption='[[3bsu]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
===Hybrid-binding domain of human RNase H1 in complex with 12-mer RNA/DNA===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3bsu]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BSU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BSU FirstGlance]. <br>
{{ABSTRACT_PUBMED_18337749}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5IU:5-IODO-2-DEOXYURIDINE-5-MONOPHOSPHATE'>5IU</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bsu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bsu OCA], [https://pdbe.org/3bsu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bsu RCSB], [https://www.ebi.ac.uk/pdbsum/3bsu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bsu ProSAT]</span></td></tr>
[[3bsu]] is a 10 chain structure of [[Ribonuclease]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BSU OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/RNH1_HUMAN RNH1_HUMAN] Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bs/3bsu_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bsu ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Ribonuclease|Ribonuclease]]
*[[Ribonuclease 3D structures|Ribonuclease 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:018337749</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Ribonuclease H]]
[[Category: Large Structures]]
[[Category: Cerritelli, S M.]]
[[Category: Cerritelli SM]]
[[Category: Crouch, R J.]]
[[Category: Crouch RJ]]
[[Category: Gaidamakov, S A.]]
[[Category: Gaidamakov SA]]
[[Category: Ghirlando, R.]]
[[Category: Ghirlando R]]
[[Category: Nowotny, M.]]
[[Category: Nowotny M]]
[[Category: Yang, W.]]
[[Category: Yang W]]
[[Category: Dsrna]]
[[Category: Hydrolase-rna-dna complex]]
[[Category: Rna/dna hybrid]]
[[Category: Rnase h]]
Retrieved from "https://proteopedia.org/3bsu"