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[[Image:1pwl.png|left|200px]]


{{STRUCTURE_1pwl|  PDB=1pwl  |  SCENE=  }}
==Crystal structure of human Aldose Reductase complexed with NADP and Minalrestat==
 
<StructureSection load='1pwl' size='340' side='right'caption='[[1pwl]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
===Crystal structure of human Aldose Reductase complexed with NADP and Minalrestat===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1pwl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PWL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PWL FirstGlance]. <br>
{{ABSTRACT_PUBMED_15146479}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.1&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BFI:2[4-BROMO-2-FLUOROPHENYL)METHYL]-6-FLUOROSPIRO[ISOQUINOLINE-4-(1H),3-PYRROLIDINE]-1,2,3,5(2H)-TETRONE'>BFI</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pwl OCA], [https://pdbe.org/1pwl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pwl RCSB], [https://www.ebi.ac.uk/pdbsum/1pwl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pwl ProSAT]</span></td></tr>
[[1pwl]] is a 1 chain structure of [[Aldose Reductase]] and [[Carboxypeptidase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PWL OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/ALDR_HUMAN ALDR_HUMAN] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pw/1pwl_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pwl ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Aldose Reductase|Aldose Reductase]]
*[[Aldose reductase 3D structures|Aldose reductase 3D structures]]
*[[Carboxypeptidase|Carboxypeptidase]]
__TOC__
 
</StructureSection>
==Reference==
<ref group="xtra">PMID:015146479</ref><references group="xtra"/>
[[Category: Aldehyde reductase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Darmanin, C.]]
[[Category: Large Structures]]
[[Category: El-Kabbani, O.]]
[[Category: Darmanin C]]
[[Category: Hazemann, I.]]
[[Category: El-Kabbani O]]
[[Category: Joachimiak, A.]]
[[Category: Hazemann I]]
[[Category: Mitschler, A.]]
[[Category: Joachimiak A]]
[[Category: Oka, M.]]
[[Category: Mitschler A]]
[[Category: Podjarny, A.]]
[[Category: Oka M]]
[[Category: Ruiz, F.]]
[[Category: Podjarny A]]
[[Category: Schneider, T R.]]
[[Category: Ruiz F]]
[[Category: Schulze-Briese, C.]]
[[Category: Schneider TR]]
[[Category: Tomizaki, T.]]
[[Category: Schulze-Briese C]]
[[Category: Aldose reductase]]
[[Category: Tomizaki T]]
[[Category: Atomic resolution]]
[[Category: Inhibitor binding]]
[[Category: Oxidoreductase]]
[[Category: Ternary complex]]
Retrieved from "https://proteopedia.org/1pwl"