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[[Image:2xdg.png|left|200px]]


{{STRUCTURE_2xdg|  PDB=2xdg  |  SCENE= }}
==Crystal structure of the extracellular domain of human growth hormone releasing hormone receptor.==
 
<StructureSection load='2xdg' size='340' side='right'caption='[[2xdg]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
===CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF HUMAN GROWTH HORMONE RELEASING HORMONE RECEPTOR.===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2xdg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XDG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XDG FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
==About this Structure==
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
[[2xdg]] is a 2 chain structure of [[Hormone]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XDG OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xdg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xdg OCA], [https://pdbe.org/2xdg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xdg RCSB], [https://www.ebi.ac.uk/pdbsum/2xdg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xdg ProSAT]</span></td></tr>
 
</table>
==See Also==
== Disease ==
*[[Hormone|Hormone]]
[https://www.uniprot.org/uniprot/GHRHR_HUMAN GHRHR_HUMAN] Isolated growth hormone deficiency type IB. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:11232012</ref> <ref>PMID:10084571</ref> <ref>PMID:12534354</ref>
== Function ==
[https://www.uniprot.org/uniprot/GHRHR_HUMAN GHRHR_HUMAN] Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xd/2xdg_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2xdg ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H.]]
[[Category: Large Structures]]
[[Category: Barr, A J.]]
[[Category: Arrowsmith CH]]
[[Category: Bountra, C.]]
[[Category: Barr AJ]]
[[Category: Brown, N Burgess.]]
[[Category: Bountra C]]
[[Category: Carpenter, E P.]]
[[Category: Burgess Brown N]]
[[Category: Chaikuad, A.]]
[[Category: Carpenter EP]]
[[Category: Delft, F Von.]]
[[Category: Chaikuad A]]
[[Category: Edwards, A.]]
[[Category: Edwards A]]
[[Category: Muniz, J R.C.]]
[[Category: Muniz JRC]]
[[Category: Pike, A C.W.]]
[[Category: Pike ACW]]
[[Category: Quigley, A.]]
[[Category: Quigley A]]
[[Category: Shrestha, L.]]
[[Category: Shrestha L]]
[[Category: Vollmar, M.]]
[[Category: Vollmar M]]
[[Category: Weigelt, J.]]
[[Category: Weigelt J]]
[[Category: Yang, J.]]
[[Category: Yang J]]
[[Category: Membrane protein]]
[[Category: Von Delft F]]
[[Category: Receptor]]
[[Category: Signaling protein]]
Retrieved from "https://proteopedia.org/2xdg"