3q8p: Difference between revisions

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[[Image:3q8p.png|left|200px]]


{{STRUCTURE_3q8p|  PDB=3q8p  |  SCENE=  }}
==Human DNA polymerase iota incorporating dCTP opposite 8-oxo-guanine==
 
<StructureSection load='3q8p' size='340' side='right'caption='[[3q8p]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
===Human DNA polymerase iota incorporating dCTP opposite 8-oxo-guanine===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3q8p]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q8P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q8P FirstGlance]. <br>
{{ABSTRACT_PUBMED_21300901}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8OG:8-OXO-2-DEOXY-GUANOSINE-5-MONOPHOSPHATE'>8OG</scene>, <scene name='pdbligand=DCP:2-DEOXYCYTIDINE-5-TRIPHOSPHATE'>DCP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q8p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q8p OCA], [https://pdbe.org/3q8p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q8p RCSB], [https://www.ebi.ac.uk/pdbsum/3q8p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q8p ProSAT]</span></td></tr>
[[3q8p]] is a 3 chain structure of [[DNA polymerase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q8P OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/POLI_HUMAN POLI_HUMAN] Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity.<ref>PMID:11013228</ref> <ref>PMID:11251121</ref> <ref>PMID:11387224</ref> <ref>PMID:12410315</ref> <ref>PMID:14630940</ref> <ref>PMID:15199127</ref> <ref>PMID:15254543</ref>


==See Also==
==See Also==
*[[DNA polymerase|DNA polymerase]]
*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:021300901</ref><references group="xtra"/>
__TOC__
[[Category: DNA-directed DNA polymerase]]
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Kirouac, K N.]]
[[Category: Large Structures]]
[[Category: Ling, H.]]
[[Category: Synthetic construct]]
[[Category: Dna polymerase]]
[[Category: Kirouac KN]]
[[Category: Transferase-dna complex]]
[[Category: Ling H]]
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