1z8a: Difference between revisions

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[[Image:1z8a.png|left|200px]]


{{STRUCTURE_1z8a|  PDB=1z8a  |  SCENE=  }}
==Human Aldose Reductase complexed with novel Sulfonyl-pyridazinone Inhibitor==
 
<StructureSection load='1z8a' size='340' side='right'caption='[[1z8a]], [[Resolution|resolution]] 0.95&Aring;' scene=''>
===Human Aldose Reductase complexed with novel Sulfonyl-pyridazinone Inhibitor===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1z8a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z8A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z8A FirstGlance]. <br>
{{ABSTRACT_PUBMED_16337231}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.95&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=62P:6-[(5-CHLORO-3-METHYL-1-BENZOFURAN-2-YL)SULFONYL]PYRIDAZIN-3(2H)-ONE'>62P</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z8a OCA], [https://pdbe.org/1z8a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z8a RCSB], [https://www.ebi.ac.uk/pdbsum/1z8a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z8a ProSAT]</span></td></tr>
[[1z8a]] is a 1 chain structure of [[Aldose Reductase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z8A OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/ALDR_HUMAN ALDR_HUMAN] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z8/1z8a_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z8a ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Aldose Reductase|Aldose Reductase]]
*[[Aldose reductase 3D structures|Aldose reductase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:016337231</ref><references group="xtra"/>
[[Category: Aldehyde reductase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Heine, A.]]
[[Category: Large Structures]]
[[Category: Klebe, G.]]
[[Category: Heine A]]
[[Category: Podjarny, A.]]
[[Category: Klebe G]]
[[Category: Steuber, H.]]
[[Category: Podjarny A]]
[[Category: Zentgraf, M.]]
[[Category: Steuber H]]
[[Category: Double conformation]]
[[Category: Zentgraf M]]
[[Category: Oxidoreductase]]
[[Category: Protein-ligand complex]]
[[Category: Tim-barrel]]
Retrieved from "https://proteopedia.org/1z8a"