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[[Image:3tzf.png|left|200px]]


{{STRUCTURE_3tzf|  PDB=3tzf  |  SCENE=  }}
==Crystal Structure of the Yersinia pestis Dihydropteroate Synthase with Sulfonamide Drug Complex.==
 
<StructureSection load='3tzf' size='340' side='right'caption='[[3tzf]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
===Crystal Structure of the Yersinia pestis Dihydropteroate Synthase with Sulfonamide Drug Complex.===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3tzf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TZF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TZF FirstGlance]. <br>
{{ABSTRACT_PUBMED_22383850}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=08D:SULFAMETHOXAZOLE'>08D</scene>, <scene name='pdbligand=HH2:6-HYDROXYMETHYLPTERIN-DIPHOSPHATE'>HH2</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tzf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tzf OCA], [https://pdbe.org/3tzf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tzf RCSB], [https://www.ebi.ac.uk/pdbsum/3tzf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tzf ProSAT]</span></td></tr>
[[3tzf]] is a 2 chain structure of [[Dihydropteroate synthase]] with sequence from [http://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TZF OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A2S9PLG4_YERPE A0A2S9PLG4_YERPE] Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.[RuleBase:RU361205]


==See Also==
==See Also==
*[[Dihydropteroate synthase|Dihydropteroate synthase]]
*[[Dihydropteroate synthase 3D structures|Dihydropteroate synthase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:022383850</ref><references group="xtra"/>
[[Category: Large Structures]]
[[Category: Dihydropteroate synthase]]
[[Category: Yersinia pestis]]
[[Category: Yersinia pestis]]
[[Category: Wu, Y.]]
[[Category: Wu Y]]
[[Category: Dihydropteroate synthase]]
[[Category: Sulfonamide complex]]
[[Category: Tim barrel]]
[[Category: Transferase-antibiotic-inhibitor complex]]
[[Category: Transferase-inhibitor-antibiotic complex]]

Latest revision as of 10:16, 1 March 2024

Crystal Structure of the Yersinia pestis Dihydropteroate Synthase with Sulfonamide Drug Complex.

3tzf, resolution 2.10Å

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