3p73: Difference between revisions

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[[Image:3p73.png|left|200px]]


{{STRUCTURE_3p73| PDB=3p73 | SCENE= }}
==Crystal Structures of the Chicken YF1*7.1 molecule==
<StructureSection load='3p73' size='340' side='right'caption='[[3p73]], [[Resolution|resolution]] 1.32&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3p73]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P73 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P73 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.32&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=16A:CETYL-TRIMETHYL-AMMONIUM'>16A</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p73 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p73 OCA], [https://pdbe.org/3p73 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p73 RCSB], [https://www.ebi.ac.uk/pdbsum/3p73 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p73 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q9BCW3_CHICK Q9BCW3_CHICK]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Chicken YF1 genes share a close sequence relationship with classical MHC class I loci but map outside of the core MHC region. To obtain insights into their function, we determined the structure of the YF1*7.1/beta(2)-microgloblin complex by X-ray crystallography at 1.3 A resolution. It exhibits the architecture typical of classical MHC class I molecules but possesses a hydrophobic binding groove that contains a non-peptidic ligand. This finding prompted us to reconstitute YF1*7.1 also with various self-lipids. Seven additional YF1*7.1 structures were solved, but only polyethyleneglycol molecules could be modeled into the electron density within the binding groove. However, an assessment of YF1*7.1 by native isoelectric focusing indicated that the molecules were also able to bind nonself-lipids. The ability of YF1*7.1 to interact with hydrophobic ligands is unprecedented among classical MHC class I proteins and might aid the chicken immune system to recognize a diverse ligand repertoire with a minimal number of MHC class I molecules.


===Crystal Structures of the Chicken YF1*7.1 molecule===
Structure of a classical MHC class I molecule that binds "non-classical" ligands.,Hee CS, Gao S, Loll B, Miller MM, Uchanska-Ziegler B, Daumke O, Ziegler A PLoS Biol. 2010 Dec 7;8(12):e1000557. PMID:21151886<ref>PMID:21151886</ref>


{{ABSTRACT_PUBMED_21151886}}
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
==About this Structure==
<div class="pdbe-citations 3p73" style="background-color:#fffaf0;"></div>
[[3p73]] is a 2 chain structure of [[Beta-2 microglobulin]] and [[Major histocompatibility complex]] with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P73 OCA].


==See Also==
==See Also==
*[[Beta-2 microglobulin|Beta-2 microglobulin]]
*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
*[[Major histocompatibility complex|Major histocompatibility complex]]
*[[MHC 3D structures|MHC 3D structures]]
 
*[[MHC I 3D structures|MHC I 3D structures]]
==Reference==
== References ==
<ref group="xtra">PMID:021151886</ref><references group="xtra"/>
<references/>
__TOC__
</StructureSection>
[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
[[Category: Daumke, O.]]
[[Category: Large Structures]]
[[Category: Gao, S.]]
[[Category: Daumke O]]
[[Category: Hee, C S.]]
[[Category: Gao S]]
[[Category: Loll, B.]]
[[Category: Hee CS]]
[[Category: Miller, M M.]]
[[Category: Loll B]]
[[Category: Uchanska-Ziegler, B.]]
[[Category: Miller MM]]
[[Category: Ziegler, A.]]
[[Category: Uchanska-Ziegler B]]
[[Category: Histocompatibility antigen]]
[[Category: Ziegler A]]
[[Category: Immune system]]
Retrieved from "https://proteopedia.org/3p73"